昆明医科大学学报2024，Vol.45Issue(12)：160-166,7.DOI:10.12259/j.issn.2095-610X.S20241223
肠道菌群及其代谢产物在动脉粥样硬化发生发展中的作用
The Role of Intestinal Flora and Its Metabolites in The Development of Atherosclerosis
摘要
Abstract
Intestinal flora and their metabolites play an important role in the occurrence and development of cardiovascular diseases such as atherosclerosis(AS),and have become an important target for the prevention and treatment of AS.In this paper,we focus on the intestinal microecological environment and focus on the relationship between intestinal flora metabolites such as trimethylamine oxide(TMAO),short-chain fatty acids(SCFA),phenylacetylglutamine(PAG),lipopolysaccharides(LPS),and bile acids(BA),and AS.At the same time,we also discuss the therapeutic strategies of AS that start from adjusting the intestinal flora and its metabolites,with the hope of opening up a new avenue of AS prevention and treatment.We hope to open up new avenues for the prevention and treatment of AS.关键词
肠道菌群/代谢产物/动脉粥样硬化/治疗Key words
Intestinal flora/Metabolites/Atherosclerosis/Treatment分类
医药卫生引用本文复制引用
王艾云,王雨婷,蔡静,倪若妍,罗彩莹,喻卓,陈鹏..肠道菌群及其代谢产物在动脉粥样硬化发生发展中的作用[J].昆明医科大学学报,2024,45(12):160-166,7.基金项目
国家自然科学基金(82360088) （82360088）
云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目(2201AY070001-001) （2201AY070001-001）
云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目(202101AY070001-020) （202101AY070001-020）
云南省老年疾病临床医学研究中心专项资金(202102AA310069). （202102AA310069）
