微小RNA在Alzheimer's病中作用的研究进展OACSTPCD
Research progress on the role of microRNA in Alzheimer's disease
Alzheimer's病(AD)是一种常见的神经退行性疾病,其病理特征是大脑中β-淀粉样蛋白斑块和神经纤维缠结的积累.微小RNA(miRNA)是一类小分子非编码RNA,是通过Dicer等酶的作用从前体miR-NA加工而来的成熟miRNA.miRNA能够通过与靶mRNA结合调控基因表达,从而在多种生物过程中发挥重要作用.研究发现,多种miRNAs在AD患者的大脑组织和外周体液中表达异常,这些miRNAs参与了 AD相关的β-淀粉样蛋白代谢、突触功能、神经元凋亡和神经炎症等过程.本文就miRNA在AD病理中的作用进行综述,为其在AD诊断和治疗中的应用提供理论基础.
Alzheimer's disease(AD)is a common neurodegenerative disease characterized by the accumulation of β-amyloid plaques and neurofibrillary tangles in the brain.MicroRNAs(miRNAs)are a class of small molecule non-coding RNAs that are maturely processed from precursor miRNAs by the action of enzymes such as Dicer.miRNAs play an important role in a variety of biological processes by binding to target mRNAs to regulate gene expression.Studies found that a variety of miRNAs were abnormally expressed in the brain tissues and peripheral body fluids of AD patients,and these miRNAs were involved in AD-related β-amyloid metabolism,synaptic function,neuronal apoptosis,and neuroinflammation.This article reviews the role of miRNA in the pathology of AD,and provides a theoretical basis for its application in the diagnosis and treatment of AD.
仲瑾;徐心然;吴婷
210029 南京医科大学第一附属医院神经内科210029 南京医科大学第一附属医院神经内科210029 南京医科大学第一附属医院神经内科
临床医学
Alzheimer's病微小RNA发病机制生物标志物治疗靶点
Alzheimer's diseasemicroRNApathogenesisbiomarkerstherapeutic target
《临床神经病学杂志》 2024 (6)
459-463,5
国家自然科学基金资助项目(81772454,81971237)江苏省科技厅社会发展项目(BE2017734)江苏省重点研发计划重点项目(BE2023023-2)
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