小脑储备的应用与进展OACSTPCD
The application and progress of cerebellar reserve
小脑作为神经领域最具探索潜力的结构之一,近年受到神经科学研究者的广泛关注.以往的研究认为,小脑主要在运动控制中发挥协调作用,但逐渐增加的证据表明,小脑是被忽视的重要认知调控脑区,它参与认知网络的整合和调节.小脑受损后会引发认知的缺陷和障碍,并进一步损害大脑认知相关网络的连接效率和信息整合能力.小脑在受到损伤或疾病影响时,能够通过自身的可塑性与适应性来恢复其原有的功能,这表明小脑本质上具有自我补偿和恢复的能力.这种独特的小脑能力被称为小脑储备.本文将就小脑储备的机制原理以及应用展开综述,旨在为脑部疾病的干预提供新的途径.
The cerebellum,as one of the most explored structures in the neurological field,has received extensive attention from neuroscience researchers in recent years.Previous studies have suggested that the cerebellum mainly plays a coordinating role in motor control,but increasing evidence suggests that the cerebellum is a neglected brain region that regulates cognition and it is involved in the integration and regulation of cognitive networks.Damage to the cerebellum triggers cognitive deficits and further impairs the connectivity efficiency and information integration of the brain's cognitive-related networks.When the cerebellum is affected by disease,it is able to recover its original function through its own plasticity and adaptability.This suggests that the cerebellum is capable of self-compensation and recovery.This unique cerebellar ability is called cerebellar reserve.This research aims to review the cerebellar reserve's mechanism and application to open up new treatment options for brain disorders.
杨舒媛;祁鑫洋;田敏捷;姚群;庄乾树;石静萍
210029 南京医科大学附属脑科医院神经内科210029 南京医科大学附属脑科医院神经内科210029 南京医科大学附属脑科医院神经内科210029 南京医科大学附属脑科医院神经内科210029 南京医科大学附属脑科医院神经内科210029 南京医科大学附属脑科医院神经内科
临床医学
小脑储备突触可塑性神经调控认知
cerebellar reservesynaptic plasticityneuromodulationcognition
《临床神经病学杂志》 2024 (6)
464-467,4
江苏省科技计划专项资金项目(重点研发计划社会发展)(BE2023669)
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