临床肝胆病杂志2024，Vol.40Issue(12)：2345-2350,6.DOI:10.12449/JCH241201
重视早发性肝内胆管癌的研究
The research on early-onset intrahepatic cholangiocarcinoma should be taken seriously
摘要
Abstract
Intrahepatic cholangiocarcinoma(ICC)is a highly malignant biliary tumor,and early-onset ICC(EOICC)refers to ICC with an age of≤50 years at the time of confirmed diagnosis and often has a higher clinical stage and more significant biological invasiveness.At present,the incidence rate of EOICC is increasing rapidly,but the research on EOICC is still in its early stage.Current evidence has shown that EOICC has significantly different epidemiological,clinical,and molecular characteristics from late-onset ICC.Therefore,the research on the high-risk factors and pathogenesis of EOICC is of great importance for the early identification,diagnosis,and targeted treatment of EOICC.Due to the younger age and better physical condition of EOICC patients,they can tolerate medical interventions with higher risks,and active individualized diagnosis and treatment regimens can be adopted,allowing patients to obtain similar survival and prognosis as those with late-onset ICC.However,due to the significant differences in molecular characteristics between EOICC and ICC,existing targeted drugs may not be suitable for EOICC patients,posing a huge challenge for the systematic treatment of patients with advanced EOICC.The clinical and basic research on EOICC is still lagging behind,and the population characteristics and pathogenic factors of EOICC should be further clarified,in order to promote the establishment of prevention,diagnosis,and treatment standards for the EOICC population.关键词
胆管上皮癌/早发性肿瘤/流行病学/体征和症状/基因表达谱Key words
Cholangiocarcinoma/Early-Onset Tumors/Epidemiology/Signs and Symptoms/Gene Expression Profiling引用本文复制引用
覃德龙,陈家璐,唐玥,李宗龙,汤朝晖,全志伟..重视早发性肝内胆管癌的研究[J].临床肝胆病杂志,2024,40(12):2345-2350,6.基金项目
国家自然科学基金(81772521) （81772521）
上海交通大学医学院附属新华医院院级临床研究培育基金(17CSK06) （17CSK06）
上海交通大学医学院多中心临床研究(DLY201807) National Nature Science Foundation of China(81772521) （DLY201807）
Clinical Training Program of Shanghai Xin Hua Hospital Affiliated to School of Medicine,Shanghai Jiaotong University(17CSK06) （17CSK06）
Multicenter Clinical Study in School of Medicine,Shanghai Jiaotong University(DLY201807) （DLY201807）
