昆明医科大学学报2024，Vol.45Issue(12)：1-9,9.DOI:10.12259/j.issn.2095-610X.S20241201
热量限制与间歇性禁食对炎症及代谢疾病的影响
The Effects of Caloric Restriction and Intermittent Fasting on Inflammation and Metabolic Diseases
摘要
Abstract
Caloric restriction(CR)and intermittent fasting(IF)are two dietary intervention strategies that have garnered increasing attention for their potential role in regulating inflammation and metabolic disorders.With the widespread adoption of high-calorie diets and sedentary lifestyles,the incidence of metabolic diseases such as obesity,type 2 diabetes,and cardiovascular diseases has risen significantly,posing major public health challenges.This review explores how CR and IF impact inflammation reduction and metabolic health improvement through mechanisms such as metabolic reprogramming,autophagy activation,and inhibition of inflammatory pathways.Notably,both strategies have shown promising intervention effects in inflammatory diseases like multiple sclerosis and systemic lupus erythematosus.Additionally,CR and IF demonstrate positive effects in the metabolic regulation of obesity,diabetes,and cardiovascular diseases.Despite their clinical potential,long-term adherence and safety remain key challenges for widespread implementation.Future research should focus on personalized interventions and the integration of multiple therapeutic approaches to further validate the clinical value of CR and IF.In summary,CR and IF offer novel,non-pharmacological strategies for managing chronic diseases,presenting significant potential for future clinical application.关键词
热量限制/间歇性禁食/免疫性疾病/炎症调节/代谢疾病Key words
Caloric Restriction/Intermittent Fasting/Immune Diseases/Inflammatory Regulation/Metabolic Diseases分类
医药卫生引用本文复制引用
张熙冰,牛玲,刘方,冉江华..热量限制与间歇性禁食对炎症及代谢疾病的影响[J].昆明医科大学学报,2024,45(12):1-9,9.基金项目
国家自然科学基金项目(82060127),春城计划高层次人才培养项目(C202214007) （82060127）
