临床肝胆病杂志2024，Vol.40Issue(12)：2464-2472,9.DOI:10.12449/JCH241217
肝静脉剥夺术与门静脉栓塞治疗剩余肝体积不足肝癌效果比较的Meta分析
Clinical efficacy of liver venous deprivation versus portal vein embolization in treatment of liver cancer with insufficient residual liver volume:A Meta-analysis
摘要
Abstract
Objective To systematically evaluate the efficacy and prognosis of liver venous deprivation(LVD)versus portal vein embolization(PVE)in the treatment of hepatic malignancies with insufficient residual liver volume.Methods This study was conducted according to PRISMA guidelines,with a PROSPERO registration number of CRD42024533292.Databases including PubMed,Embase,the Cochrane Library,Web of Science,CNKI,Wanfang Data,and VIP were searched for articles on the efficacy of LVD versus PVE.According to the inclusion and exclusion criteria,related articles were screened for quality assessment and extraction of clinical data for LVD and PVE,and related data were summarized and analyzed.RevMan 5.3 was used to perform the Meta-analysis.Results A total of 12 articles(all cohort studies)were included,involving 644 patients(245 in the LVD group and 399 in the PVE group).The Meta-analysis showed that there were significant differences between the two groups in FLR growth rate after embolization(standardized mean difference[SMD]=0.84,95%confidence interval[CI]:0.59-1.09,P<0.05),daily growth volume of FLR after embolization(SMD=1.19,95%CI:0.64-1.73,P<0.05),the incidence rate of complications after embolization(risk ratio[RR]=1.59,95%CI:1.06-2.38,P<0.05),interval between embolization and second-stage surgery(SMD=-0.81,95%CI:-1.32 to-0.29,P<0.05),and the completion rate of second-stage surgery(RR=1.09,95%CI:1.01-1.18,P<0.05).Conclusion Compared with PVE,LVD can enable patients to achieve FLR for surgery in a relatively short period of time,thereby reducing the incidence rate of disease progression,solving the problem of hypertrophic deficiency,achieving a higher second-stage surgical resection rate,and bringing more benefits to patients with liver cancer.In addition,LVD has similar safety profiles to PVE during second-stage surgery.关键词
肝肿瘤/肝静脉剥夺/门静脉栓塞/Meta分析Key words
Liver Neoplasms/Liver Vein Deprivation/Portal Vein Embolism/Meta-Analysis引用本文复制引用
闫凯峰,胡小杰,刘宏..肝静脉剥夺术与门静脉栓塞治疗剩余肝体积不足肝癌效果比较的Meta分析[J].临床肝胆病杂志,2024,40(12):2464-2472,9.基金项目
山西省自然科学基金(201901D111350) Natural Science Foundation of Shanxi Province(201901D111350) （201901D111350）
