临床肝胆病杂志2024，Vol.40Issue(12)：2505-2512,8.DOI:10.12449/JCH241222
外周时钟基因在非酒精性脂肪性肝炎发展与防治中的作用
Role of peripheral clock genes in the progression,prevention,and treatment of nonalcoholic steatohepatitis
摘要
Abstract
As a severe clinical manifestation of nonalcoholic fatty liver disease,nonalcoholic steatohepatitis(NASH)is characterized by lipid deposition and inflammatory damage in the liver.At present,clinical medications for NASH are still in the exploratory phase,and it is urgent to make progress.Recent studies have shown that the pathogenesis of NASH is associated with circadian rhythm disorders in the liver,with the specific manifestation of dysregulated expression of liver clock genes such as BMAL1,which increases hepatic lipogenesis,reduces fatty acid oxidation,and activates pro-inflammatory factors.Therefore,improving circadian rhythm of the liver and regulating the expression of liver clock genes are feasible strategies for the prevention and treatment of NASH.Currently,some medications for NASH via activating the proteins encoded by clock genes have been applied in animal experiments,for example,the REVERB full-agonist SR9009 can inhibit the development of liver inflammation,which confirms the possibility of NASH treatment by targeting the proteins encoded by clock genes.This article summarizes the role of hepatic clock genes in regulating lipid metabolism and the development and progression of inflammation in the liver and elaborates on the recent advances in medications targeting clock genes and the proteins encoded by clock genes,in order to provide new targets for the treatment of NASH.关键词
非酒精性脂肪性肝病/昼夜节律/时钟蛋白质类Key words
Non-alcoholic Fatty Liver Disease/Circadian Rhythm/CLOCK Proteins引用本文复制引用
刘思言,田静怡,黄雨扬,谷天麒,邓茗月,杨攀..外周时钟基因在非酒精性脂肪性肝炎发展与防治中的作用[J].临床肝胆病杂志,2024,40(12):2505-2512,8.基金项目
重庆市自然科学基金(cstc2020jcyj-bshX0068) （cstc2020jcyj-bshX0068）
2021年重庆市中青年高端人才项目(yxgdrc20210101) （yxgdrc20210101）
2022年国家级创新训练项目(202210631001) Natural Science Foundation of Chongqing(cstc2020jcyj-bshX0068) （202210631001）
2021 Chongqing Municipal Middle and Young Age High-end Talent Project(yxgdrc20210101) （yxgdrc20210101）
2022 National Level Innovation Training Project(202210631001) （202210631001）
