昆明医科大学学报2024，Vol.45Issue(12)：65-74,10.DOI:10.12259/j.issn.2095-610X.S20241209
基底膜蛋白表达对子宫内膜癌及其免疫浸润的关系分析
Analysis on the Expression of Basement Membrane Protein in Endometrial Carcinoma and Its Relationship with Immune Invasion
摘要
Abstract
Objective Immune infiltration,as well as their implications across various cancers,and to establish a clinical prognostic model based on the findings.Methods The expression profile and clinical information of endometrial cancer tissue and adjacent tissues in TCGA endometrial cancer database were used,the differential expression genes were screened out for analysis,and the mRNA co-expressed by LncRNA was analyzed by GO enrichment and KEGG signaling pathway.The differential genes between endometrial cancer and adjacent tissues were intersected with the basement membrane protein genes.The selected differentially expressed genes were combined with survival status and survival time to screen out Hub genes by Lasso-cox regression analysis.Multivariate Cox regression analysis was used to establish a prognostic model,and pan-cancer analysis and immunoinfiltration correlation analysis were further performed.Results Six basal membrane protein Hub genes,ADAMTS5,EVA1C,THBS4,CTSD,ITGAV and LAMA1,were identified as associated with the prognosis of patients with endometrial cancer,and found that the survival rate of patients decreased significantly with the increase of risk score.Pan-cancer analysis found that these 6 genes were significantly different in most cancer types,and high expression in GBMLGG(glioma),LGG(low-grade glioma of the brain),LAML(acute myeloid leukemia),UVM(Uveal melanoma),ACC(adrenal cortical cancer)and other cancers had poor prognosis.The potential role of these genes in tumor immunotherapy was also explored,and significant negative correlation was found with Th 17 cells,Th2 cells,NK CD56 bright cells and other immune cells(P＜0.01),and significant positive correlation was found with Tcm,iDC,Eosinophils,aDC and other immune cells(P＜0.01).Conclusion Basal membrane protein gene has high clinical value in the diagnosis and prognosis of endometrial cancer,and can be used as a prognostic marker and potential therapeutic target for patients with endometrial cancer.关键词
基底膜蛋白基因/子宫内膜癌/预后/免疫浸润Key words
Basement membrane protein gene/Endometrial carcinoma/Prognosis/Immune infiltration分类
医药卫生引用本文复制引用
张莺,罗相如,王星,赵盼,廉坤,李元琴,邵明琨..基底膜蛋白表达对子宫内膜癌及其免疫浸润的关系分析[J].昆明医科大学学报,2024,45(12):65-74,10.基金项目
昆明医科大学第二附属医院人才梯队项目后备人才(RCTDHB202312) （RCTDHB202312）
