临床肝胆病杂志2024，Vol.40Issue(12)：2538-2542,5.DOI:10.12449/JCH241227
药物性肝损伤的免疫学机制
Immunological mechanism of drug-induced liver injury
摘要
Abstract
Drug-induced liver injury(DILI)has a complex mechanism involving various pathways with a synergistic effect on each other and a causal relationship with each other,among which immune response plays an important role in the pathogenesis of DILI.In the context of genetic background,drug active metabolites,drug-molecule complexes,and danger signal molecules may be used as the trigger factors for immune response in DILI,activating the mechanism of drug antigenic hypersensitivity,P-i hypothesis,and danger signal mechanism in innate immunity.The cascade reaction of innate immunity and adaptive immunity leads to the imbalance of the innate immune tolerance of the liver and thus causes immunoinflammatory injury of liver tissue.This article mainly elaborates on the immunological mechanism of DILI,in order to provide new ideas for the research and development of therapeutic targets for DILI and the methods for avoiding adverse drug reactions.关键词
化学性与药物性肝损伤/免疫/治疗学Key words
Chemical and Drug Induced Liver Injury/Immunity/Therapeutics引用本文复制引用
王宇,李爽,刘成海..药物性肝损伤的免疫学机制[J].临床肝胆病杂志,2024,40(12):2538-2542,5.基金项目
国家自然科学基金(82305099) （82305099）
宝山区卫生健康委优青(育才)计划资助(BSWSYC-2024-07) （育才）
新一轮(2023-2025年度)宝山区医学重点学(专)科及特色品牌建设项目(BSZK-2023-BZ07) National Natural Science Foundation of China(82305099) （2023-2025年度）
Supported by Youqing(Yucai)Program of Baoshan District Health and Wellness Committee(BSWSYC-2024-07) （Yucai）
A New Round(2023-2025)of Key Medical Disciplines and Characteristic Brand Building Projects in Baoshan District(BSZK-2023-BZ07) （2023-2025）
