昆明医科大学学报2024，Vol.45Issue(12)：129-134,6.DOI:10.12259/j.issn.2095-610X.S20241218
淋巴细胞亚群对脑缺血再灌注损伤认知功能障碍的早期预测价值
Early Predictive Value of Lymphocyte Subsets for Cognitive Dysfunction in Cerebral Ischemia-reperfusion Injury
摘要
Abstract
Objective To explore the early predictive value of lymphocyte subsets for cognitive impairment in cerebral ischemia-reperfusion injury.Methods A study was conducted on 68 patients with cerebral ischemia admitted to Honghe Hospital affiliated to Kunming Medical University from January 2023 to December 2023,divided into observation group(n=30)and control group(n=38).The general situation,lymphocyte subsets detection results and Montreal Cognitive Assessment Scale(MoCA)score were compared.Their correlation,sensitivity,specificity were analyzed.Results The proportion of patients with diabetes and levels of CD3+,CD8+and MoCA score in the observation group were lower than those in the control group(P＜0.05),the levels of CD4+,CD4+/CD8+,NK and CD19+in the observation group were higher than those in the control group(P＜0.05);CD3+and CD8+were positively correlated with MoCA score(P＜0.05);CD4+,CD4+/CD8+,NK and CD19+were negatively correlated with MoCA score(P＜0.05).The sensitivity and specificity of lymphocyte subsets combined detection for the diagnosis of cognitive dysfunction in cerebral ischemia-reperfusion injury were 93.45％and 100.00％,respectively.Conclusion The lymphocyte subsets have good predictive value for the occurrence of cognitive dysfunction in cerebral ischemia-reperfusion injury.It can be used as a specific marker.关键词
脑缺血/再灌注损伤/认知功能障碍/淋巴细胞亚群Key words
Cerebral ischemia/Reperfusion injury/Cognitive dysfunction/Lymphocyte subsets分类
医药卫生引用本文复制引用
屈继波,祝玲,候炳辉,白松,谢安木..淋巴细胞亚群对脑缺血再灌注损伤认知功能障碍的早期预测价值[J].昆明医科大学学报,2024,45(12):129-134,6.基金项目
青岛大学医疗集团科研基金资助重点项目(YLJT20221006) （YLJT20221006）
