皮肤性病诊疗学杂志2024，Vol.31Issue(12)：801-809,9.DOI:10.3969/j.issn.1674-8468.2024.12.001
神经梅毒脑脊液代谢组学分析:潜在诊断生物标记物的鉴定
Metabolomic profiling of cerebrospinal fluid in neurosyphilis:identification of potential diag-nostic biomarkers
贺媛媛 1吴嘉欣 2陈钊琪 2邓梓亮 1王海鹰 1柯吴坚2
作者信息
- 1. 南方医科大学公共卫生学院,广东 广州 510515
- 2. 南方医科大学皮肤病医院,广东 广州 510091
- 折叠
摘要
Abstract
Objective This study aims to analyze metabolites in the cerebrospinal fluid(CSF)of neu-rosyphilis patients to identify potential diagnostic markers.Methods Untargeted metabolomics by liquid chro-matography-mass spectrometry was used to analyze metabolites in CSF samples from five neurosyphilis and five syphilis/non-neurosyphilis patients.After quality control and normalization,data analyses(principal compo-nent analysis,orthogonal partial least squares-discriminant analysis,hierarchical clustering)were conducted to identify differential metabolites.Results The content of metabolites(Pro-leu,nudifloramide,N-oleoyl gly-cine,DMP 777,(±)-propionylcarnitine,and 3β-hydroxy-5-cholenoic acid)in neurosyphilis patients was 1.7-to 4.5-fold of that in the non-neurosyphilis patients.Conclusions The metabolites,particularly nudiflo-ramide and N-oleoyl glycine,which have been implicated in other neurological disorders,warrant further inves-tigation into their roles in the pathogenesis of neurosyphilis.关键词
神经梅毒/代谢组学分析/脑脊液/诊断生物标志物Key words
neurosyphilis/metabolomic profiling/cerebrospinal fluid/diagnostic biomarkers引用本文复制引用
贺媛媛,吴嘉欣,陈钊琪,邓梓亮,王海鹰,柯吴坚..神经梅毒脑脊液代谢组学分析:潜在诊断生物标记物的鉴定[J].皮肤性病诊疗学杂志,2024,31(12):801-809,9.
