皮肤性病诊疗学杂志2024，Vol.31Issue(12)：825-831,7.DOI:10.3969/j.issn.1674-8468.2024.12.004
5 438例女性人乳头瘤病毒感染的特点及与宫颈细胞学的相关性分析
Analysis of the characteristics of HPV infection and its correlation with cervical cytology in 5 438 women
摘要
Abstract
Objective To reveal the current status of human papillomavirus(HPV)infection in the cervix among women in the Maoming district,and analyze the characteristics of subtype dis-tribution,and its correlation with the results of cervical cytologic test(TCT).Methods HPV testing was carried out in 27 071 women at Maoming People's Hospital from January 2022 to De-cember 2023.Among them,24 900 subjects underwent TCT testing.The HPV infection status,characteristics of subtype distribution,and their relationship with cervical lesions were analyzed.Results Among 27 071 women,5 438 subjects were tested positive for HPV,with an infection rate of 20.09％.The five most common genotypes were HPV52(19.92％),HPV58(8.96％),HPV16(8.83％),HPV53(6.88％),and HPV81(6.15％).Over 12％of individuals(1 244/10 237,12.15％)undergoing routine physical examinations were positive for HPV.There were significant differences in HPV infection rates between the patients and those who underwent routine physical examination in all age groups(all P＜0.001).Among the 24 900 patients who underwent both HPV and TCT tests,3 676 cases showed single-genotype infections,among which 1 176 ca-ses(31.99％)were TCT positive.A total of 1 236 cases were multiple-genotype infections,with TCT positive in 605 cases(48.95％).The TCT positive rate was higher in those with multiple-genotype HPV infections than those with single-genotype infections(X2=128.86,P＜0.001).Among the TCT positive cases,the top five HPV subtypes were HPV52(19.20％),HPV16(12.46％),HPV58(8.91％),HPV53(6.96％),and HPV51(5.76％).The HPV infection rate was significantly higher in TCT positive individuals than TCT negative individuals(X2=5340.19,P＜0.001).Conclusions In the Maoming district,HPV infection in women is primari-ly characterized by single-genotype infection.The characteristics of subtype HPV infection are consistent with previous reports.However,substantial portion of women with TCT positive are in-fected with HPV53 and HPV51,warranting attention.关键词
人乳头瘤病毒/液基细胞学/亚型分布Key words
human papillomavirus/thinprep cytologic test/subtype distribution引用本文复制引用
黎永坚,莫观海,张朝浩..5 438例女性人乳头瘤病毒感染的特点及与宫颈细胞学的相关性分析[J].皮肤性病诊疗学杂志,2024,31(12):825-831,7.基金项目
广东省医学科学技术研究基金(B2023297) （B2023297）
