皮肤性病诊疗学杂志2024，Vol.31Issue(12)：842-849,8.DOI:10.3969/j.issn.1674-8468.2024.12.007
基于生物信息学探讨类泛素化修饰在银屑病中的作用机制并药物敏感性分析
Using bioinformatics to reveal the pathogenic mechanisms of small ubiquitin-like modifica-tion in psoriasis and to predict drug sensitivity
摘要
Abstract
Objective Using bioinformatics to assess the expression levels and regulatory mechanisms of small ubiquitin-related modifier(SUMO)in psoriasis,and to analyze its effect on metabolism.Methods R language(3.3.6 version)was used to determine the difference in ex-pression levels of SUMO between psoriatic patients and controls,and the receiver operating char-acteristic(ROC)curve of SUMO.The interaction network of SUMO was built using the website of GeneMANIA.The network gene enrichment analysis software GSVA was used to determine the en-richment pathway of SUMO in the psoriasis dataset.XGBOOST and random forest were used to screen dominant genes and verify their differential expression.pRRophetic was used to identify po-tential drugs targeting SUMO in the psoriasis dataset.Results SUMO1,SUMO3,SUMO1P3,SUMO2P3 were highly expressed in psoriasis-involved skin.SUMO interacted with multiple meta-bolic pathways in psoriasis.SUMO1 could be the gene most closely related to metabolic pathways.Conclusions SUMO mRNA is highly expressed in psoriasis-involved skin,and SUMO1 may be involved in the onset and development of psoriasis by regulating the metabolic process.关键词
银屑病/类泛素化修饰/SUMO/代谢Key words
psoriasis/small ubiquitin-like modification/SUMO/metabolism引用本文复制引用
袁立燕,余晓玲,何雪瑜..基于生物信息学探讨类泛素化修饰在银屑病中的作用机制并药物敏感性分析[J].皮肤性病诊疗学杂志,2024,31(12):842-849,8.基金项目
国家自然科学基金(82103724),广东省科技计划项目(2022A1515111018),广东省中医药课题(20231109),广州市科技计划项目(202201011412) （82103724）
