岭南现代临床外科2024，Vol.24Issue(5)：314-319,6.DOI:10.3969/j.issn.1009-976X.2024.05.008
外科感染PVL阳性金黄色葡萄球菌患者粒淋比相关性研究
Surgical patients infect PVL-positive Staphylococcus aureus correlation study of neutrophils and lymphocytes
摘要
Abstract
Objective To understand the prevalence and resistance of Staphylococcus aureus(S.aureus)carrying the Panton-Valentine leukocidin(PVL)gene in surgical patients at the Shandong Provincial Hospital Affiliated to Shandong First Medical University in 2023.The clinical application values of white blood cell(WBC),C-reactive protein(CRP),and neutrophil-to-lymphocyte ratio(NLR)in the diagno-sis of PVL-positive S.aureus infection were investigated.Methods 100 strains of S.aureus were iso-lated.The presence of the mecA gene and genes encoding PVL were ditermined using PCR,and the drug resistance of the isolates were analyzed.Groups were grouped according to the mecA and PVL gene test results.Contemporaneous 100 subjects undergoing healthy physical examination were selected as the control group.The levels of WBC,CRP,and NLR of each group were collected,and the clinical application values of WBC,CRP,and NLR for PVL-positive S.aureus infection were compared.Results Among the 100 strains of S.aureus,47 isolates were Methicillin-resistant Staphylococcus aureus(MRSA).Of the 49 S.aureus strains tested,the PVL gene was detected in most of them,which were mainly methicillin-sensitive Staphylococcus aureus(MSSA).The levels of WBC,CRP,and NLR increased significantly during S.aureus infection,and the level of NLR in the PVL-positive group was significantly higher than that in the PVL-negative group(Z=-2.26,P=0.02).Still,the levels of WBC,and CRP were rarely differ-ent between the PVL-positive group and PVL-negative group.Conclusion Compared with WBC and CRP,NLR had a higher clinical application value for PVL-positive S.aureus,and NLR can be used as a predictor of PVL-positive S.aureus infection.关键词
金黄色葡萄球菌/Panton-Valentine杀白细胞素/耐甲氧西林金黄色葡萄球菌/C反应蛋白/中性粒细胞与淋巴细胞比值Key words
Staphylococcus aureus/Panton-Valentine leucocidin/Methicillin-resistant Staphylococcus aureus/C-reactive protein/Neutrophil-to-lymphocyte ratio分类
医药卫生引用本文复制引用
张乐,王月玲,白媛媛,宋真,鹿星伦,吴玉龙..外科感染PVL阳性金黄色葡萄球菌患者粒淋比相关性研究[J].岭南现代临床外科,2024,24(5):314-319,6.基金项目
山东省自然基金项目(ZR2020MH306) （ZR2020MH306）
