岭南现代临床外科2024，Vol.24Issue(5)：330-334,5.DOI:10.3969/j.issn.1009-976X.2024.05.011
肝移植围手术期使用艾沙康唑治疗毛孢子菌感染有效2例并经验分享
The infection of Trichosporon effectively treated with isavuconazole during the perioperative period for liver transplantation:two cases report and experience sharing
麦汉滔 1张克林 1郭瑞莲 1庄苏园 1何清1
作者信息
- 1. 中山大学孙逸仙纪念医院肝移植ICU,广州10289
- 折叠
摘要
Abstract
Objective To explore the feasibility of isavuconazole in the treatment of Trichosporon infection and share clinical experience.Methods Through a retrospective analysis of the treatment process of two cases of pneumonia caused by Trichosporon during the perioperative period of liver trans-plantation at our hospital,combined with the study of relevant literature,we summarize the characteristics and treatment points of trichosporonosis,as well as the evaluate the feasibility of using isavuconazole to treat trichosporonosis.Results Two patients underwent liver transplantation for"liver failure,"and the lung trichosporonosiswas detected earlier through metagenomic next-generation sequencing technology before the operation.After treatment with amphotericin B failed,two patients were treated with isavucon-azole in combination.Case 1 was also complicated with pulmonary Aspergillus fumigatus infection after surgery.The treatment of isavuconazolefor nearly 10 months showed improvement in both pulmonary lesions on imaging and negative results of fungal etiology for many times.Case 2 was treated with isavuconazole for 2 weeks and finally cured.As of the submission date,case 1 patient had died and Case 2 patient was still alive.Conclusion Isavuconazole is a potentially effective drug for trichosporonosis.关键词
艾沙康唑/毛孢子菌/肝衰竭/肝移植Key words
isavuconazole/trichosporon/liver failure/liver transplantation分类
医药卫生引用本文复制引用
麦汉滔,张克林,郭瑞莲,庄苏园,何清..肝移植围手术期使用艾沙康唑治疗毛孢子菌感染有效2例并经验分享[J].岭南现代临床外科,2024,24(5):330-334,5.
