实验动物与比较医学2024，Vol.44Issue(6)：661-666,6.DOI:10.12300/j.issn.1674-5817.2024.069
猫冠状病毒基因特点分析及其研究进展
Genetic Characteristics and Research Progress of Feline Coronavirus
摘要
Abstract
Feline coronavirus(FCoV)is classified into two biotypes:feline infectious peritonitis virus(FIPV)and feline enteric coronavirus(FECV).FIPV and FECV might evolve and mutate via genetic recombination and mutation,leading to novel subtypes and variants.This study examined the genomic structure and biological subtyping of FCoV,analyzed the infection characteristics of FIPV and FECV,and investigated the mechanisms of FECV transforming into FIPV.The findings revealed that while their genome structures were fundamentally similar,differences in their ability to efficiently infect monocytes/macrophages significantly influenced their pathogenicity and transmission characteristics,with FIPV exhibiting higher virulence.Moreover,the analysis of the open reading frames(ORF)3/7 as well as the N/S sequences of FIPV indicated that its non-structural proteins were associated with modulation of the host immune system.These proteins enabled immune evasion,leading to more severe disease.The genomic variability of FCoV constitutes an important foundation for studying the pathogenicity and epidemiology of FIPV and FECV,and offers references for virus detection and drug development.关键词
猫冠状病毒/猫传染性腹膜炎病毒/猫肠道冠状病毒/猫传染性腹膜炎/基因组Key words
Feline coronavirus/Feline infectious peritonitis virus/Feline enteric coronavirus/Feline infectious peritonitis/Genome分类
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陶凌云..猫冠状病毒基因特点分析及其研究进展[J].实验动物与比较医学,2024,44(6):661-666,6.基金项目
上海市科技计划项目"猫冠状病毒核酸检测方法的建立、流行病学调查及基因遗传进化分析"(20140900500) （20140900500）
