实验动物与比较医学2024，Vol.44Issue(6)：691-694,4.DOI:10.12300/j.issn.1674-5817.2024.070
一例干扰素受体缺失小鼠自发未成熟型睾丸畸胎瘤诊断
Preliminary Diagnosis and Characterization of a Spontaneous Immature Testicular Teratoma in an Interferon Receptor-Deficient Mouse Model
摘要
Abstract
Objective To observe the spontaneous testicular tumors in interferon receptor-deficient mice(AG129)and provide a basis for further research using this mouse strain.Methods The AG129 mouse population was bred in an SPF barrier environment and reproduced normally.Among the 3-week-old weaned mice,we found that one male mouse had an abnormally enlarged testis,while none of the other mice in the same litter exhibited a similar condition.The spontaneous testicular tumor in this mouse was continuously monitored.The mouse was euthanized and dissected at 9 weeks of age.The gross morphology of the tumor was observed,and the tissue was then embedded in paraffin and sectioned for hematoxylin and eosin(HE)staining.Results After several weeks of observation,the tumor tissue gradually increased in size as the mice aged.Upon dissection,the tumor tissue was encapsulated in a smooth capsule.After opening the capsule,the tumor tissue was irregular in shape,with some areas being hard and others soft.The results of HE staining showed that the tumor tissue developed from tissues derived from multiple germ layers,with nerve tissue,bone tissue,muscle tissue,and adipose tissue inside,exhibiting an irregular morphological structure.Conclusion Based on the tumor development,gross morphological structure,and the HE staining results of the pathological sections,the tumor in this mouse was preliminarily diagnosed as an immature teratoma.关键词
干扰素受体/小鼠/睾丸/未成熟型畸胎瘤Key words
Interferon receptor/Mouse/Testicle/Immature teratoma分类
医药卫生引用本文复制引用
赵赫,张帆,肖宇宙,安学芳,张涛,李丽..一例干扰素受体缺失小鼠自发未成熟型睾丸畸胎瘤诊断[J].实验动物与比较医学,2024,44(6):691-694,4.基金项目
国家重点研发计划项目"基于新靶点的重大传染病人源化动物模型研发"(2021YFF0702000) （2021YFF0702000）
湖北省科技厅项目"实验动物生物安全标准化建设"(2022DFE023) （2022DFE023）
