实验动物与比较医学2024，Vol.44Issue(6)：695-699,5.DOI:10.12300/j.issn.1674-5817.2024.092
一例新西兰白兔系统性淀粉样变性病理学诊断
Pathological Diagnosis of Systemic Amyloidosis in a New Zealand White Rabbit
摘要
Abstract
Objective To provide a reference for the diagnosis of amyloidosis in experimental animals through the pathological diagnosis of systemic amyloidosis in a case of a New Zealand white rabbit.Methods In a 6-month repeated ocular toxicity study,an abnormal finding was noted during the routine gross anatomical examination of one New Zealand white rabbit.Its organs were prepared as paraffin sections and stained with hematoxylin-eosin(HE)staining and Congo red staining.The histopathological features were observed under optical and polarized light microscopy.Results Gross anatomical examination of the animal revealed an enlarged spleen and changes in the color and texture of the lung.HE staining showed that the splenic tissue structure was destroyed,the white pulp of the spleen was surrounded by dense amyloid deposition in the form of nodular rings,along with pressure atrophy of the white pulp.Amyloid deposits were also observed in the submandibular lymph nodes,mesenteric lymph nodes,ileum,sacculus rotundus,vermiform appendix,jejunum,cecum,and rectum.Congo red staining showed that the amyloid deposition in the affected organs appeared salmon-pink,and exhibited characteristic apple green birefringence under polarized light microscopy.Conclusion The histo-pathological features of the New Zealand white rabbit are consistent with the diagnostic characteristics of systemic amyloidosis.关键词
淀粉样变性/脾脏/病理形态学/新西兰白兔Key words
Amyloidosis/Spleen/Pathological morphology/New Zealand white rabbit分类
农业科技引用本文复制引用
林晴晴,戴锦龙,陈志森,郭健敏,杨威..一例新西兰白兔系统性淀粉样变性病理学诊断[J].实验动物与比较医学,2024,44(6):695-699,5.基金项目
广东省科技计划项目(科技创新平台类)"广东省药物非临床评价研究企业重点实验室"(2023B1212070029) （科技创新平台类）
广东省重大人才工程项目"'广东特支计划'科技创业领军人才-杨威"(2021TY060021) （2021TY060021）
