同济大学学报（医学版）2024，Vol.45Issue(6)：791-796,6.DOI:10.12289/j.issn.2097-4345.24049
纤维蛋白原/白蛋白比值联合乳酸脱氢酶预测下肢动脉硬化闭塞症支架植入术后预后的价值
Pridiction value of fibrinogen/albumin ratio combined with lactate dehydrogenase levels for occurrence of major adverse limb events in patients with lower extremity arteriosclerotic obliterans after stent implantation
摘要
Abstract
Objective To investigate the value of fibrinogen to albumin ratio(FAR)combined lactate dehydrogenase(LDH)level in predicting the occurrence of major adverse limb event(MALE)in patients with lower limb atherosclerotic obliterans(ASO)following stent implantation.Methods Clinical data of 227 ASO patients who underwent endoluminal stent implantation in Department of Vascular Surgery,the First Affiliated Hospital of Naval Military Medical University between January 2020 and December 2021 were retrospectively analyzed.MALE occurred within 1 year after stent implantation in 73 cases(MALE group)and did not occur in 154 cases(no-MALE group).The gender,age,history of hypertension,type 2 diabetes mellitus(T2DM),renal insufficiency,smoking history,body mass index(BMI),post-procedure medication regimen,pre-procedure blood counts,blood biochemistry,coagulation function,target vessel location,the type,number,length and mean diameter of implanted stents,and post-procedure distal outflow tract were compared between two groups.The risk factors for MALE within 1 year after stent implantation was analyzed with multivariate logistic regression.Results Logistic regression analysis showed that FAR and LDH were independent risk factors for MALE occurrence after stent implantation(P＜0.05).Receiver operating characteristic(ROC)curve analysis revealed that the area under the curve(AUC)of FAR and LDH in predicting risk MALE occurrence was 0.618(95％CI:0.541-0.692;P=0.004)and 0.608(95％CI:0.529-0.688;P=0.004),with an optimal cut-off value,sensitivity,and specificity of 9.32,59.51％,58.92％,and 202.25 U/L,61.22％,56.93％,respectively.The AUC of the combination of FAR and LDH was 0.645(95％CI:0.568-0.722;P＜0.001),with a sensitivity and specificity of 63.06％and 64.44％,respectively.Conclusion The incidence of MALE within 1 year following stent implantation in ASO patients is correlated with FAR and LDH levels,the combination of two indicators has a better predictive value for risk of MALE.关键词
纤维蛋白原与白蛋白比值/乳酸脱氢酶/预后/下肢动脉硬化闭塞症Key words
fibrinogen to albumin ratio/lactate dehydrogenase/prognosis/atherosclerotic occlusive分类
医药卫生引用本文复制引用
李大志,朱江,李涛,雍熙,袁良喜..纤维蛋白原/白蛋白比值联合乳酸脱氢酶预测下肢动脉硬化闭塞症支架植入术后预后的价值[J].同济大学学报（医学版）,2024,45(6):791-796,6.基金项目
国家自然科学基金(82270521,81970413) （82270521,81970413）
上海长海医院临床新技术孵育项目(2024XC109) （2024XC109）
