癌症中lncRNA调控可变剪接的生物信息学研究进展OACSTPCD

Alternative splicing refers to the process that genes produce RNA isoforms under different splicing modes,and it is an important mechanism for post-transcriptional expression regulation of genes.Alternative splicing has been proved to play an important role in the occurrence and development of cancer,and abnormal splicing is considered as an important symbol of tumor occurrence.Long noncoding RNA(lncRNA)is an important participant and regulator in the process of gene alternative splicing,and many evidences show that lncRNA can affect the occurrence and development of cancer by regulating alternative splicing.In this paper,the research on alternative splicing regulated by lncRNA in cancer is reviewed,and the related bioinformatics tools and databases are summarized.