四川精神卫生2024，Vol.37Issue(6)：497-501,556,6.DOI:10.11886/scjsws20240530003
无抽搐电休克治疗联合药物治疗对住院精神分裂症患者的疗效及城乡差异
Efficacy of modified electroconvulsive therapy combined with medication in inpatient schizophrenia patients and urban-rural differences
谢宏成 1刘可智 2冯双双 3王婷婷 3梁峻钒 3仁佳俊 3张虹俐 4林资圆 3王思入 3向波3
作者信息
- 1. 西南医科大学附属医院,四川 泸州 646000||西南医科大学,四川 泸州 646000
- 2. 西南医科大学附属医院,四川 泸州 646000||自贡市精神卫生中心,四川 自贡 643020
- 3. 西南医科大学附属医院,四川 泸州 646000
- 4. 西南医科大学,四川 泸州 646000
- 折叠
摘要
Abstract
Background Combination of antipsychotic drugs and modified electroconvulsive therapy(MECT)is currently a commonly used method for treating schizophrenia,but its efficacy varies among different patient groups.Objective To explore the therapeutic effects of MECT on schizophrenia patients living in different urban versus rural environments,so as to provide references for the selection of treatment plans based on patients'residence.Methods A total of 587 patients hospitalized at Luzhou Mental Health Center,Zigong Mental Health Center and Yibin Fourth People's Hospital from May 2018 to August 2022,who met the diagnostic criteria for schizophrenia in the Diagnostic and Statistical Manual of Mental Disorders,fifth edition(DSM-5),were included in the study.Patients were divided into two groups:medication-only group(n=106)and MECT combined with medication group(n=481).In MECT combined with medication group,24 rural patients residing in urban areas were excluded,leaving the remaining patients divided into urban group(n=103)and rural group(n=354)based on their place of residence.Positive and Negative Syndrome Scale(PANSS)was used to assess the severity of symptoms.Clinical efficacy was evaluated using PANSS score reduction rate,and covariance analysis was used to compare the therapeutic effects of different patients.Results The differences of reduction rate of PANSS total score,positive symptom scale score and negative symptom scale score as well as treatment effectiveness rate between MECT combined with medication group and medication-only group were statistically significant(F=11.149,12.111,31.725,χ2=14.010,P<0.01).Statistically significant differences were also observed in reduction rate of PANSS total score and positive symptom subscale score as well as treatment effectiveness rate between urban and rural patients in MECT combined with medication group(F=3.946,4.523,χ2=4.033,P<0.05).Conclusion The efficacy of MECT combined with medication may be superior to medication alone in the treatment of schizophrenia,and the combined therapy may be more effective in urban patients than that in rural patients,with potentially more pronounced improvements in positive symptoms.关键词
精神分裂症/无抽搐电休克治疗/城乡Key words
Schizophrenia/Modified electroconvulsive therapy/Urban and rural areas分类
临床医学引用本文复制引用
谢宏成,刘可智,冯双双,王婷婷,梁峻钒,仁佳俊,张虹俐,林资圆,王思入,向波..无抽搐电休克治疗联合药物治疗对住院精神分裂症患者的疗效及城乡差异[J].四川精神卫生,2024,37(6):497-501,556,6.
