四川精神卫生2024，Vol.37Issue(6)：502-506,5.DOI:10.11886/scjsws20230910003
松弛疗法联合舍曲林治疗儿童青少年首发抑郁发作的效果
Efficacy of relaxation therapy combined with sertraline in the treatment of new-onset depressive episode in children and adolescents
摘要
Abstract
Background The depressive episode is one of the most prevalent mental illnesses worldwide.Relaxation therapy as a psychotherapy for depressive disorder has shown itself to be a viable tool,yet the existing research on relaxation therapy combined with sertraline in the treatment of depressive episodes in children and adolescents is severely limited.Objective To discuss the effect of relaxation therapy combined with sertraline on the new-onset depressive episodes in children and adolescents,and to provide references for the treatment of depressive episodes in children and adolescents.Methods From January 1,2019 to December 31,2020,a sample of 422 children and adolescents with depressive episodes attending the Child Mental Health Department of Sichuan Mental Health Center and fulfilling the International Classification of Diseases,tenth edition(ICD-10)diagnostic criteria were enrolled,and they were classified into study group(n=208)and control group(n=214)using random number table method.All participants were offered sertraline,based on this,study group was assigned to relaxation therapy for 25～30 min per day,five days per week for a period of two weeks.Hamilton Depression Scale 24-item(HAMD-24)and Hamilton Anxiety Scale(HAMA)were applied at the enrollment,the end of 2 weeks of treatment and the end of the 2nd week after discharge.Results A total of 369 patients completed the study,including 185 in study group and 184 in control group.Analysis on HAMD-24 scores revealed a significant time effect,group effect and time×group interaction effect(F=813.279,17.625,8 994.905,P<0.01).Significant time effect,group effect,and time×group interaction effect were noted on HAMA scores(F=635.041,10.716,13 945.986,P<0.01).A reduction in HAMD-24 and HAMA scores was reported in study group at end of 2 weeks of treatment and end of the 2nd week after discharge compared with baseline(t=0.924,0.359,P<0.01).At the end of the 2nd week after discharge,study group scored lower on HAMD-24 and HAMA compared to control group(t=0.210,0.720,P<0.05).At the end of 2 weeks of treatment,study group resulted in greater improvements in depressive symptoms and anxiety symptoms than those of control group(95.14％vs.66.30％,89.18％vs.71.74％,χ2=78.942,22.526,P<0.05).The overall efficacy rate yielded no statistical difference between two groups at end of the 2nd week after discharge(P>0.05),and no statistical difference was found in the adverse reactions between the two groups(P>0.05).Conclusion Compared with sertraline alone,its combination with relaxation therapy may achieve a better short-term efficacy in the treatment of depressive episode in children and adolescents.关键词
儿童青少年/抑郁发作/松弛疗法Key words
Children and adolescents/Depressive episode/Relaxation therapy分类
临床医学引用本文复制引用
刘妍,敬琳,赵荔,周晓秋,王蕊,蒋威巍,李杨,王丹..松弛疗法联合舍曲林治疗儿童青少年首发抑郁发作的效果[J].四川精神卫生,2024,37(6):502-506,5.基金项目
四川省医学科研课题(项目名称:药物联合工娱治疗治疗儿童首发抑郁障碍疗效观察,项目编号:S18020) Funded by Sichuan Medical Scientific Research Project(number,S18020) （项目名称:药物联合工娱治疗治疗儿童首发抑郁障碍疗效观察,项目编号:S18020）
