实用医学杂志2024，Vol.40Issue(24)：3476-3481,6.DOI:10.3969/j.issn.1006-5725.2024.24.007
伤害指数联合脑电双频指数监测下全身麻醉在腹腔镜结直肠癌根治术中的应用
Application of general anesthesia under nociception index combined with BIS monitoring in laparoscopic radical resection of colorectal cancer
摘要
Abstract
Objective To evaluate the Nociception Index(NOX)combined with Bispectral Index(BIS)monitoring of anesthesia management during laparoscopic radical resection of colorectal cancer.Methods A total of 80 patients,regardless of gender,aged 50 to 80 years old,and ASA grade Ⅰ or Ⅱ,chose to undergo elective laparoscopic colorectal surgery under total intravenous anesthesia.They were randomly divided into two groups:NOX combined with BIS group(Group N)and BIS alone group(Group C),with 40 cases in each group.Group N maintains an appropriate analgesia depth(NOX value is 30～50)and sedation depth(BIS value is 40～60),and group C maintains an appropriate sedation depth(BIS 40～60)and is covered with opaque cards Hide NOX and adjust the appropriate analgesia depth based on the experience of the anesthesiologist.The main observational indi-cator is the intraoperative remifentanil dosage,and the secondary observational indicators include the intraoperative propofol and cisatracurium dosage,vasoactive drug use,anesthesia recovery and extubation time,postoperative NRS pain score and sufen.The dosage of Titanyl,adverse reactions such as agitation in the postoperative recovery period,postoperative nausea and vomiting,dizziness,and intraoperative awareness.Results The amount of remi-fentanil used during the operation in group N was significantly less than that in group C(P＜0.05).The time of postoperative recovery and extubation in group N was significantly earlier than that in group C(P＜0.05).The number of cases of intraoperative use of vasoactive drugs,the incidence of postoperative agitation during recovery,postoperative nausea and vomiting,and dizziness in group N were significantly lower than those in group C(P＜0.05).There were no significant differences in the amount of propofol and cis-atracurium used during surgery and the incidence of awareness between the two groups(P＞0.05).The NRS scores of patients in group N were signifi-cantly lower than those in group C at 2,4,6,and 24 hours after surgery(P＜0.05),while there was no signifi-cant difference in the NRS scores between the two groups at 48 hours after surgery(P＞0.05).The consumption of sufentanil in group N was significantly lower than that in group C during the first 12 hours and 12 to 24 hours after surgery(P＜0.05).There was no significant difference in the consumption of sufentanil between the two groups during the second 24 to 48 hours after surgery(P＞0.05).Conclusion Compared with BIS monitoring alone,the use of NOX combined with BIS monitoring can maintain relatively stable intraoperative hemodynamics,reduce the amount of general anesthesia drugs,accelerate postoperative anesthesia recovery,improve the quality of anesthesia recovery,and reduce acute postoperative pain,which is beneficial to patients postoperative recovery.关键词
伤害指数/脑电双频指数/全身麻醉/结直肠癌/术后康复Key words
nociception index/bispectral index/general anesthesia/colorectal cancer/postopera-tive rehabilitation分类
医药卫生引用本文复制引用
邓伟,彭丹,胡海军,张静,余树春,黄松..伤害指数联合脑电双频指数监测下全身麻醉在腹腔镜结直肠癌根治术中的应用[J].实用医学杂志,2024,40(24):3476-3481,6.基金项目
国家自然科学基金资助项目(编号:82160371) （编号:82160371）
江西省卫生健康委科技计划(编号:202210595) （编号:202210595）
