重度颅脑创伤后垂体功能减退的发生现状及影响因素OACSTPCD

Objective To investigate the current status and influencing factors of pituitary dysfunction after severe craniocere-bral trauma.Methods A total of 200 patients with severe craniocerebral trauma admitted to Songshanhu Central Hospital in Dongguan City were selected and divided into two groups according to whether the patients suffered from hypopituitarism(45 cases)and normal group(155 cases).The differences of clinical data between the two groups were investigated and compared,the related factors that might affect pituitary function were compared and Logistics regression analysis was conducted.Results The incidence of pituitary dys-function in 200 severe patients was 22.50%,mainly thyroid function,adrenal function and gonadal function.The incidence of Glasgow Coma Scale(GCS)score<5,intracranial pressure≥20 mmHg,midline displacement≥5 mm,cerebral herniation,diffuse cerebral edema,skull base fracture,ICU stay>10 days and hospitalization>28 days in the reduced group was higher than that in the normal group(P<0.05).According to logistic regression analysis,the risk factors for pituitary dysfunction included GCS score<5,intracrani-al pressure≥20 mmHg,midline displacement≥5 mm,skull base fracture and diffuse cerebral edema.The inclusion of GCS score<5,intracranial pressure≥20 mmHg,midline displacement≥5 mm,skull base fracture and diffuse cerebral edema in receiver operat-ing characteristic(ROC)analysis had higher clinical value in predicting pituitary dysfunction by combining various risk factors.Conclusions The risk of pituitary dysfunction after severe craniocerebral trauma is closely related to factors such as intracranial pres-sure,skull base fractures,diffuse brain edema,GCS scores and other factors.Clinical attention and timely intervention should be paid to ensure the life safety of patients.