不同剂量奥美拉唑治疗十二指肠球部溃疡的临床疗效及对其胃内pH值的影响OA

Objective To investigate the clinical efficacy of different doses of omeprazole in the treatment of duodenal ulcer and its effect on gastric pH.Methods A total of 72 patients with duodenal ulcer admitted to Le'an County People's Hospital from July 2020 to June 2023 were selected as the research objects.According to the random number table method,they were divided into control group and study group,with 36 patients in each group.The control group was treated with conventional dose of omeprazole,and the study group was treated with high-dose omeprazole.The clinical efficacy,immune function[immunoglobulin M(IgM),immunoglobulin A(IgA),immunoglobulin G(IgG)],gastric pH changes(average gastric pH within 24 hours,time required for pH to reach 4.0 and 6.0,and duration after reaching),inflammatory factor levels[tumor necrosis factor-α(TNF-α),interleukin-8(IL-8),interleukin-17(IL-17)]were compared between the two groups.Results The total effective rate of treatment in the study group was higher than that in the control group(P＜0.05).After treatment,the levels of IgM,IgA and IgG in the two groups increased,and the levels of IgM,IgA and IgG in the study group were higher than those in the control group(P＜0.05).There was no significant difference in the average pH value in the stomach within 24 hours and the duration of pH value reaching 4.0 and 6.0 between the two groups(P＞0.05).The time required for the pH value to reach 4.0 and the pH value to reach 6.0 in the study group was higher than that in the control group(P＜0.05).After treatment,the levels of TNF-α,IL-8 and IL-17 in the two groups were lower than those before treatment,and those in the study group were lower than those in the control group(P＜0.05).Conclusion High-dose treatment of patients with duodenal bulb ulcer has a definite effect,which can improve the gastric pH value and immune function,reduce the level of inflammatory factors.It is worthy of clinical application.