银杏二萜内酯葡胺联合阿托伐他汀钙片对急性脑梗死、脑梗死恢复期患者神经功能、抗氧化能力的影响OA
Effects of Ginkgo Diterpene Lactone Meglumine Combined with Atorvastatin Calcium Tablets on Neurological Function and Antioxidant Capacity in Patients with Acute Cerebral Infarction and Convalescent Cerebral Infarction
目的 研究银杏二萜内酯葡胺联合阿托伐他汀钙片对急性脑梗死、脑梗死恢复期患者神经功能、抗氧化能力的影响.方法 选取 2022 年 1 月-2023 年 9 月在我院诊治的 66 例急性脑梗死和脑梗死恢复期患者为研究对象,采用随机数字表法分为对照组(n=33)和观察组(n=33),对照组采用阿托伐他汀钙片治疗,观察组在对照组基础上给予银杏二萜内酯葡胺治疗.比较两组治疗总有效率、神经功能缺损评分、抗氧化能力指标[过氧化氢酶(CAT)、超氧化物歧化酶(SOD)、总抗氧化能力(TAC)]、生存质量水平(QOLISP)及不良反应发生率.结果 观察组治疗总有效率(93.94%)高于对照组(81.82%)(P＜0.05);两组NIHSS评分均低于治疗前,且观察组低于对照组(P＜0.05);两组SOD、CAT、TAC 均高于对照组,且观察组高于对照组(P＜0.05);两组QOLISP评分均高于治疗前,且观察组高于对照组(P＜0.05);观察组不良反应发生率与对照组比较,差异无统计学意义(P＞0.05).结论 银杏二萜内酯葡胺联合阿托伐他汀钙片治疗急性脑梗死、脑梗死恢复期患者均具有显著的效果,可提高治疗总有效率,降低神经功能缺损评分,提高生存质量水平和抗氧化水平,且不会增加不良反应发生率,值得临床应用.
Objective To study the effects of ginkgo diterpene lactone meglumine combined with atorvastatin calcium tablets on neurological function and antioxidant capacity in patients with acute cerebral infarction and convalescent cerebral infarction.Methods A total of 66 patients with acute cerebral infarction and convalescent cerebral infarction diagnosed and treated in our hospital from January 2022 to September 2023 were selected as the research objects.They were divided into control group(n=33)and observation group(n=33)by random number table method.The control group was treated with atorvastatin calcium tablets,and the observation group was treated with ginkgo diterpene lactone meglumine on the basis of the control group.The total effective rate,neurological deficit score,antioxidant capacity index[catalase(CAT),superoxide dismutase(SOD),total antioxidant capacity(TAC)],quality of life(QOLISP)and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group(93.94%)was higher than that in the control group(81.82%)(P<0.05).The NIHSS score of the two groups was lower than that before treatment,and that of the observation group was lower than that of the control group(P<0.05).SOD,CAT and TAC in the two groups were higher than those in the control group,and those in the observation group were higher than those in the control group(P<0.05).The QOLISP score of the two groups was higher than that before treatment,and that of the observation group was higher than that of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusion Ginkgo diterpene lactone meglumine combined with atorvastatin calcium tablets has a significant effect in the treatment of patients with acute cerebral infarction and convalescent cerebral infarction,which can improve the total effective rate of treatment,reduce the neurological deficit score,improve the quality of life level and antioxidant level,and will not increase the incidence of adverse reactions.It is worthy of clinical application.
黄实方
湖口县人民医院神经内科,江西 湖口 332500
临床医学
银杏二萜内酯葡胺阿托伐他汀钙急性脑梗死恢复期神经功能
Ginkgo diterpene lactone meglumineAtorvastatin calciumAcute cerebral infarctionRecovery periodNeurological function
《医学信息》 2024 (24)
114-117,4
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