应用化学2024，Vol.41Issue(12)：1679-1696,18.DOI:10.19894/j.issn.1000-0518.240348
纳米酶在眼部疾病治疗中的研究进展
Research Progress on Nanozymes in the Treatment of Ophthalmic Diseases
摘要
Abstract
Moderate levels of reactive oxygen species (ROS) are essential in modulating a range of physiological processes in living organisms. An increase in ROS content can result in oxidative stress and harm to biological molecules,resulting in various diseases. Due to prolonged exposure to light,the eyes with high metabolic activity are especially vulnerable to oxidative stress,which is strongly associated with the onset and progression of various ophthalmic diseases. Therefore,it is crucial to eliminate ROS and maintain oxidation-reduction homeosta. With the progress of nanotechnology,nanozymes with enzyme-like activities,such as catalase (CAT) and superoxide dismutase (SOD),have attracted extensive attention due to their stability,ease of preparation,and good biocompatibility,in regulating oxidation-reduction homeosta and alleviating ROS-related damage. In this review,we systematically summarize the relationship between reactive oxygen species and ophthalmic diseases,the research progress of nanozymes in the treatment of ophthalmic diseases,and the challenges and difficulties in clinical translation.关键词
纳米酶/眼部疾病/活性氧Key words
Nanozymes/Ophthalmic diseases/Reactive oxygen species分类
化学化工引用本文复制引用
刘爽,滕思莹,惠鹏,孙雅彬..纳米酶在眼部疾病治疗中的研究进展[J].应用化学,2024,41(12):1679-1696,18.基金项目
吉林省科技发展项目(No.20200201424JC)资助Supported by the Science and Technology Development Project of Jilin Province(No.20200201424JC) （No.20200201424JC）
