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中药活性肽的制备、分离纯化及鉴定研究进展

刘长龙 张昊皓 杨天硕 李云霄

医学信息2024,Vol.37Issue(23):186-192,7.
医学信息2024,Vol.37Issue(23):186-192,7.DOI:10.3969/j.issn.1006-1959.2024.23.044

中药活性肽的制备、分离纯化及鉴定研究进展

Research Progress on Preparation,Separation,Purification and Identification of Active Peptides from Traditional Chinese Medicine

刘长龙 1张昊皓 1杨天硕 1李云霄2

作者信息

  • 1. 山东中医药大学第二附属医院制剂中心,山东 济南 250000
  • 2. 山东第一医科大学附属内分泌与代谢病医院药剂科,山东 济南 250001
  • 折叠

摘要

Abstract

In recent years,studies have found that active peptides derived from leech,eupolyphaga,centipede and other traditional Chinese medicines have significant anticoagulant,blood lipid regulation,anti-tumor and other pharmacological activities.The structure and chemical properties of active peptides are similar.The key to the study is to select appropriate preparation,separation and identification methods to obtain active peptides from traditional Chinese medicine.However,compared with food,aquaculture and other industries,there are relatively few studies on the separation,purification and identification of active peptides from traditional Chinese medicine.Therefore,this paper reviews the methods of preparation,separation,purification and identification of active peptides from traditional Chinese medicine in recent years,and expounds its principles and characteristics,in order to provide reference for the development and application of active peptides from traditional Chinese medicine.

关键词

中药活性肽/分离纯化/柱层析/膜分离/质谱/结构鉴定

Key words

Active peptides from traditional Chinese medicine/Separation and purification/Column chromatography/Membrane separation/Mass spectrum/Structural identification

分类

医药卫生

引用本文复制引用

刘长龙,张昊皓,杨天硕,李云霄..中药活性肽的制备、分离纯化及鉴定研究进展[J].医学信息,2024,37(23):186-192,7.

基金项目

山东省重大科技创新工程项目(编号:2019JZZY020906) (编号:2019JZZY020906)

医学信息

1006-1959

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