中国病理生理杂志2024，Vol.40Issue(12)：2359-2366,8.DOI:10.3969/j.issn.1000-4718.2024.12.021
MGP翻译后修饰及其抑制血管钙化分子机制的研究进展
Progress in post-translational modification and molecular mechanism of MGP as a vascular calcification inhibitor
摘要
Abstract
The matrix gamma-carboxyglutamate protein(MGP),a vitamin K-dependent protein,inhibits arte-rial calcification.The substance's ability to inhibit calcification is linked to its post-translational modifications,specifical-ly γ-glutamyl carboxylation and phosphorylation.The molecular mechanism of the calcification inhibitor remains unclear due to its low solubility and complicated post-translational modifications.In this section,we summarize current research and ongoing debates about post-translational modifications of MGP and its mechanism for inhibiting calcification.We re-viewed recent research on diseases associated with MGP deficiency,such as cardiovascular disease,chronic kidney dis-ease,and Keutel syndrome.Hopefully,this review can help us understand how MGP functions as a vascular calcification inhibitor and identify potential treatments for diseases resulting from its dysfunction.关键词
基质γ-羧基谷氨酸蛋白/翻译后修饰/钙化抑制Key words
matrix gamma-carboxyglutamate protein/post-translational modification/calcification inhibition分类
医药卫生引用本文复制引用
洪敏雯,李清峰,刘康,梁丹,李世新,郝振宇..MGP翻译后修饰及其抑制血管钙化分子机制的研究进展[J].中国病理生理杂志,2024,40(12):2359-2366,8.基金项目
国家自然科学基金资助项目(No.82370136) （No.82370136）
江苏省自然科学基金资助项目(No.BK20210828 （）
No.BK20231333) （）
江苏省特聘教授资助项目 （）
江苏省高等学校自然科学基金面上项目(No.21KJB610002) （No.21KJB610002）
中国博士后科学基金面上项目(No.2023M732983) （No.2023M732983）
