中国中西医结合杂志2024，Vol.44Issue(12)：1457-1461,5.DOI:10.7661/j.cjim.20241120.242
黄莪胶囊联合坦索罗辛治疗良性前列腺增生症合并慢性前列腺炎随机对照研究
Huang'e Capsules Combined with Tamsulosin in the Treatment of Prostate Hyperplasia Combined with Chronic Prostatitis:A Randomized Controlled Study
摘要
Abstract
Objective To compare the clinical efficacy of Huang'e Capsules(HC)combined with tamsulosin in the treatment of benign prostatic hyperplasia(BPH)combined with prostatitis(CP).Methods A total of 150 patients diagnosed with BPH combined with CP were randomly assigned to tamsulosin group,HC group,and combination group,with 50 patients in each group.The tamsulosin group received oral tamsulosin 0.2 mg per night.The HC group received oral HC,4 capsules per time,3 times per day.The combination group received both tamsulosin and HC.The main therapeutic index included prostate volume,prostate symptoms assessed by International Prostate Symptom Scale(IPSS).The secondary efficacy index included Chinese medicine(CM)symptom score,maximum flow rate(Qmax),National Institutes of Health Chronic Prostatitis Symptom Index(NIH-CPSI),Quality of Life score(QOL).The adverse reactions were observed in the 3 groups.Results Totally 42 cases in tamsulosin group,41 cases in HC group,40 cases in combination group finished the study,and included in the statistical analysis.Compared with before treatment in the same group,IPSS,CM symptom score,QOL,total score,discomfort symptom,urination symptom,life treatment,symptom severity score of NIH-CPSI decreased,Qmax increased after treatment in all groups(P＜0.05).Prostate volume decreased after treatment in HC group and combination group(P＜0.05).Compared with tamsulosin group and HC group at the same time,IPSS,CM symptom score,QOL,total score,discomfort symptom,urination symptom,life treatment score of NIH-CPSI decreased,Qmax increased after treatment in combination group(P＜0.05).There was no statistical significance in adverse reaction between the 3 groups(P＞0.05).Conclusion The combination of HC and tamsulosin improve prostate symptoms,quality of life,and CM symptom score in the treatment of BPH combined with CP patients.关键词
黄莪胶囊/坦索罗辛/前列腺炎/前列腺增生/中成药/中西医结合/随机对照试验Key words
Huang'e Capsules/tamsulosin/prostatitis/prostatic hyperplasia/Chinese patent medicine/integrative medicine/randomized controlled trial引用本文复制引用
陈嘉兴,王超洋,胡凌云..黄莪胶囊联合坦索罗辛治疗良性前列腺增生症合并慢性前列腺炎随机对照研究[J].中国中西医结合杂志,2024,44(12):1457-1461,5.基金项目
浙江省医学会课题基金(No.2022ZYC-A121) （No.2022ZYC-A121）
浙江省医药卫生科技计划项目(No.2022RC291) （No.2022RC291）
江山市科技局指导性项目(No.JS2022D031) （No.JS2022D031）
