福建农林大学学报（自然科学版）2025，Vol.54Issue(1)：89-99,11.DOI:10.13323/j.cnki.j.fafu(nat.sci.).202402009
长链非编码RNA编码微肽的鉴定和功能研究进展
Advances in identification and functional studies of micropeptides encoded by long non-coding RNAs
摘要
Abstract
Rapid technological advances in translational sequencing,peptidomics and bioinformatics analysis enable researchers to establish a significant number of long non-coding RNAs(lncRNAs)containing small open reading frame(sORF)which is capable of encoding functional micropeptides.These micropeptides,encoded by lncRNAs,play crucial roles in regulating physiological processes such as skeletal muscle function,embryonic development and neural cell development.Furthermore,they can also impact the progression of various tumors,inflammatory responses and cardiovascular diseases.Investigating the functions of these micropep-tides is not only of great significance for gaining deeper understanding of the regulatory mechanisms underlying physiological and pathological processes,but also provides novel approaches for the prevention and treatment of related diseases.This article details the current methods on identifying and characterizing lncRNA-coded micropeptides,and highlights the up-to-date research progress on their functions,aiming to provide a comprehensive update and guidelines for relevant follow-up studies.关键词
长链非编码RNA/短开放阅读框/微肽/鉴定/功能Key words
long non-coding RNAs/small open reading frames/micropeptides/identification/function分类
畜牧业引用本文复制引用
黄桂英,王李伟,刘嘉茵,王松,陈吉龙,池晓娟..长链非编码RNA编码微肽的鉴定和功能研究进展[J].福建农林大学学报（自然科学版）,2025,54(1):89-99,11.基金项目
国家自然科学基金项目(U23A20235) （U23A20235）
福建农林大学科技创新专项(KFB23094). （KFB23094）
