长链非编码RNA编码微肽的鉴定和功能研究进展OA北大核心

Rapid technological advances in translational sequencing,peptidomics and bioinformatics analysis enable researchers to establish a significant number of long non-coding RNAs(lncRNAs)containing small open reading frame(sORF)which is capable of encoding functional micropeptides.These micropeptides,encoded by lncRNAs,play crucial roles in regulating physiological processes such as skeletal muscle function,embryonic development and neural cell development.Furthermore,they can also impact the progression of various tumors,inflammatory responses and cardiovascular diseases.Investigating the functions of these micropep-tides is not only of great significance for gaining deeper understanding of the regulatory mechanisms underlying physiological and pathological processes,but also provides novel approaches for the prevention and treatment of related diseases.This article details the current methods on identifying and characterizing lncRNA-coded micropeptides,and highlights the up-to-date research progress on their functions,aiming to provide a comprehensive update and guidelines for relevant follow-up studies.