福建师范大学学报（自然科学版）2025，Vol.41Issue(1)：87-94,8.DOI:10.12046/j.issn.1000-5277.2024090021
代谢工程改造酵母合成单萜类化合物研究进展
Research Progress on Metabolic Engineering of Yeast for Monoterpenoids Synthesis
摘要
Abstract
Monoterpenoids are a class of compounds with a molecular structure consisting of two isoprene units,containing a total of 10 carbon atoms.They are commonly found in the secretory tis-sues of higher plants.Their oxygenated derivatives,such as alcohols,aldehydes,and ketones,exhibit high biological activity and are frequently used to produce preservatives,deodorants,disin-fectants,and other products.Traditionally,monoterpenoids have been obtained through natural product extraction and chemical synthesis.However,with the continuous innovation and develop-ment of synthetic biology technology,the use of microorganisms as metabolic factories for production has become an inevitable trend,offering advantages such as low cost,high controllability,and sig-nificant potential for scalability.This review summarizes the research progress in the production of monoterpenoids using yeast as a chassis,focusing on three aspects:metabolic pathway engineering,enzyme engineering,and cell engineering,demonstrating the applicability and effectiveness of met-abolic engineering transformation methods for the production of natural active products in microorgan-isms.关键词
酵母/单萜/合成生物学/代谢工程/代谢调控Key words
yeast/monoterpenoids/synthetic biology/metabolic engineering/metabolic regu-lation分类
生物学引用本文复制引用
李陈曦,杨清华,黄建忠,祁峰..代谢工程改造酵母合成单萜类化合物研究进展[J].福建师范大学学报（自然科学版）,2025,41(1):87-94,8.基金项目
国家自然科学基金项目(32272287) （32272287）
国家糖料产业技术体系项目(CARS-170501) （CARS-170501）
