福建师范大学学报（自然科学版）2025，Vol.41Issue(1)：95-101,7.DOI:10.12046/j.issn.1000-5277.2024070019
细菌水解NAD+抵御噬菌体感染的机制研究进展
Progress in the Study of the Mechanism by Which Bacteria Hydrolyze of NAD+to Defend Against Bacteriophage Infection
摘要
Abstract
Over the course of long-term evolution,bacteria have employed CRISPR-Cas systems,restriction-modification,and other immune systems to combat phage infections.In recent years,dozens of novel anti-phage systems have been identified,with a common mechanism that induces the death or metabolic stasis of infected cells through highly diverse ways,thereby preven-ting the further amplification of phages.Current studies have shown that phage infection can activate effector proteins with NAD+hydrolase function,triggering rapid hydrolysis of NAD+.This review summarizes the molecular mechanisms of newly discovered effector proteins that hydrolyze NAD+to exert anti-phage invasion effects,providing theoretical basis and new perspectives for the prevention and control of pathogenic bacteria and the development of efficient phage preparations.关键词
NAD+/NAD+水解酶/抗噬菌体/毒素/流产感染Key words
NAD+/NAD+hydrolase/phage resistance/toxin/abortive infection分类
生物科学引用本文复制引用
吴书娴,张丹丹,甄向凯..细菌水解NAD+抵御噬菌体感染的机制研究进展[J].福建师范大学学报（自然科学版）,2025,41(1):95-101,7.基金项目
国家自然科学基金项目(821700145) （821700145）
福建省中青年教师教育科研项目(JAT220048) （JAT220048）
