康复学报2024，Vol.34Issue(6)：625-632,8.DOI:10.3724/SP.J.1329.2024.06014
经颅磁刺激治疗神经病理性疼痛作用机制研究
Mechanism of Transcranial Magnetic Stimulation Therapy for Neuropathic Pain
摘要
Abstract
Neuropathic pain(NP)is a persistent and refractory chronic pain condition resulting from damage or disease of the somatosensory nervous system.Its complex pathogenesis,coupled with low clinical remission rate,significantly impairs the physical and mental well-being of the affected individuals.As a mature non-invasive neuromodulation technique,transcranial magnetic stimu-lation(TMS)can generate transient magnetic pulses penetrating through the skull,induce changes in cortical neuronal potentials,and affect the function and structure of the nervous system,which can not only alleviate NP-related symptoms,but also improve NP-related emotional disorders.However,there is no consensus on the neurobiological mechanism of TMS-induced analgesia.This study reviews the neurobiological mechanisms of TMS in alleviating NP from the aspects of regulation of synaptic plasticity,func-tional reorganization of neural network(inducing cortical-cortical functional connectivity and subcortical brain region functional connectivity),sensitivity of afferent nerve fibers,neurotransmitter levels and neuroimmunity based on the mechanism of TMS,in or-der to provide a basis for the treatment of NP by TMS.However,there are still some shortcomings,such as insufficient in-depth study of synaptic plasticity,the lack of further refinement in the research of the sensitivity of afferent nerve fibers,and the limitation of neuroimmune research.It is necessary to carry out multi-center and large sample studies,explore the mechanism of TMS regula-ting neural network by using new techniques such as cranial electroencephalogram,and promote the application of paired-pulse TMS in clinical research related to NP,so as to provide more reliable evidence for the treatment of NP with TMS.关键词
神经病理性疼痛/经颅磁刺激/突触可塑性/神经网络/神经生物学机制Key words
neuropathic pain/transcranial magnetic stimulation/synaptic plasticity/neural network/neurobiological mecha-nism引用本文复制引用
孙雨佳,张军风,闫隆,范诗宇,钱玉林,丛珊,王煜,于涛..经颅磁刺激治疗神经病理性疼痛作用机制研究[J].康复学报,2024,34(6):625-632,8.基金项目
国家自然科学基金项目(82205279) （82205279）
2023年天津中医药大学研究生科研创新项目(YJSKC-20232004) （YJSKC-20232004）
