分析化学2024，Vol.52Issue(12)：1785-1796,12.DOI:10.19756/j.issn.0253-3820.241130
无机声敏剂在肿瘤治疗和诊断中的研究进展
Recent Advances in Inorganic Sonosensitizers for Tumor Diagnosis and Treatment
摘要
Abstract
Sonodynamic therapy(SDT)is an emerging approach of cancer treatment that stimulates sonosensitizers by ultrasound to produce reactive oxygen species(ROS)and induce cancer cell death.Compared with organic sonosensitizers,inorganic sonosensitizers have many advantages in stability,toxicity,water solubility,tumor targeting and functional regulation,showing extensive potentials in diagnosis and treatment of tumors.Thanks to the excellent properties,numerous sonosensitizers based on inorganic nanomaterials have been reported,mainly including titanium-based sonosensitizers,other metal-based sonosensitizers and non-metal-based sonosensitizers,and their prospects in diagnosis and treatment of tumor have been discussed.This review introduced the mechanism of SDT,overviewed the research progress of different systems of inorganic sonosensitizers in treatment and diagnosis of tumor,and summarized the methods to improve the therapeutic effect of SDT.Finally,the existing problems and development perspective of inorganic sonosensitizers were discussed and prospected.关键词
无机声敏剂/声动力治疗/成像诊断/评述Key words
Inorganic sonosensitizers/Sonodynamic therapy/Imaging diagnosis/Review引用本文复制引用
刘新静,张若浩,付欣玉,冯婧,张洪杰..无机声敏剂在肿瘤治疗和诊断中的研究进展[J].分析化学,2024,52(12):1785-1796,12.基金项目
国家自然科学基金基础科学中心项目(No.22388101)和吉林省科技发展计划项目(Nos.20220101063JC,20240601050RC,YDZJ202302CXJD065)资助. Supported by the Basic Science Center Project of the National Natural Science Foundation of China(No.22388101)and the Program of Science and Technology Development Plan of Jilin Province of China(Nos.20220101063JC,20240601050RC,YDZJ202302CXJD065). （No.22388101）
