广西医学2024，Vol.46Issue(11)：1670-1675,6.DOI:10.11675/j.issn.0253-4304.2024.11.06
LISA技术联合DUOPAP治疗新生儿呼吸窘迫综合征的临床效果
Clinical effect of LISA technique combined with DUOPAP for the treatment of neonatal respiratory distress syndrome
摘要
Abstract
Objective To observe the application effect of less invasive surfactant administration(LISA)technique combined with duo positive airway pressure(DUOPAP)in neonatal respiratory distress syndrome(NRDS).Methods A total of 80 children with NRDS were selected as the research subjects,and they were randomly assigned to LISA+DUOPAP group or intubation-surfactant-extubation(INSURE)+nasal continuous positive airway pressure(NCPAP)group,with 40 cases in each group.The pre-and post-treatment blood gas analysis indices,and adverse reactions,indices related to hospitalization,clinical efficacy,and occurrence states of complications during administration were compared between children of the two groups.Results After treatment,both groups exhibited elevated PaO2 and pH value as compared with before treatment,and the LISA+DUOPAP group yielded higher PaO2 and pH value as compared with the INSURE+NCPAP group;in addition,both groups presented a decreased PaCO2as compared with before treatment,and the LISA+DUOPAP group interpreted a lower PaCO2 as compared with the INSURE+NCPAP group(P＜0.05).During administration,the LISA+DUOPAP group depicted a lower drug reflux rate as compared with the INSURE+NCPAP group(P＜0.05),but there was no statistically significant difference in the incidence rate of carbon dioxide retention and bradycardia between the two groups(P＞0.05).The LISA+DUOPAP group indicated shorter adjuvant ventilation time,total oxygen use time,length of hospital stay,and a lower total hospitalization expense as compared with the INSURE+NCPAP group(P＜0.05),but there was no statistically significant difference in the total effective rate between the two groups(P＞0.05).The total incidence rate of complications in the LISA+DUOPAP group was lower than that in the INSURE+NCPAP group(P＜0.05),but there was no statistically significant difference in the incidence rate of various complications(bronchopulmonary dysplasia,premature periventricular intraventricular hemorrhage,retinopathy of prematurity,neonatal necrotizing enterocolitis)between the two groups(P＞0.05).Conclusion Compared with INSURE technique combined with NCPAP,LISA technique combined with DUOPAP for the treatment of NRDS can preferably ameliorate blood gas indices and oxygenation,shorten length of hospital stay,reduce hospitalization expense,and decrease the total incidence rate of complications.关键词
新生儿呼吸窘迫综合征/微创肺表面活性物质给药技术/无创呼吸支持/双水平气道正压通气/临床效果Key words
Neonatal respiratory distress syndrome/Less invasive surfactant administration/Non-invasive respiratory support/Duo positive airway pressure/Clinical effect分类
医药卫生引用本文复制引用
吴战朋,周红亮,殷爱云..LISA技术联合DUOPAP治疗新生儿呼吸窘迫综合征的临床效果[J].广西医学,2024,46(11):1670-1675,6.基金项目
连云港市妇幼健康科研项目(F202106) （F202106）
