工业微生物2024，Vol.54Issue(6)：1-3,3.DOI:10.3969/j.issn.1001-6678.2024.06.001
基于液相色谱-质谱联用技术的微生物药物代谢研究
Research on Microbial Drug Metabolism Based on Liquid Chromatography-Mass Spectrometry
曹小庆 1魏理杨 1杨琴1
作者信息
- 1. 重庆市南岸区疾病预防控制中心,重庆 401336
- 折叠
摘要
Abstract
Microorganisms participate in drug conversion through a unique enzyme system,which can lead to increased or decreased drug activities,and even produce toxic metabolites.Liquid chromatography-mass spectrometry(LC-MS)technology,based on its high resolution and sensitivity,can accurately determine the concentration of drugs and their metabolites,and provide detailed information about the impact of microorganisms on drug metabolism,thereby supporting the decision-making process of drug development and safety assessment.Therefore,this article will explore microbial drug metabolism based on liquid chromatography-mass spectrometry technology,in order to provide theoretical references for modern medicine.关键词
液相色谱-质谱联用技术/微生物/药物代谢Key words
liquid chromatography-mass spectrometry technology/microorganisms/drug metabolism引用本文复制引用
曹小庆,魏理杨,杨琴..基于液相色谱-质谱联用技术的微生物药物代谢研究[J].工业微生物,2024,54(6):1-3,3.
