工业微生物2024，Vol.54Issue(6)：69-74,6.DOI:10.3969/j.issn.1001-6678.2024.06.021
小鼠肠道细菌E.caecimuris GAM9抑制单增李斯特菌感染的作用研究
Study on the Inhibition of Listeria Monocytogenes Infection by E.caecimuris GAM9 Isolated from the Intestinal Tract of Mice
摘要
Abstract
The isolation of functional bacteria from the gut microbiota as a new approach for finding alternative antibiotic treatments has been widely studied in the treatment of pathogenic microorganisms.The study isolated a strain of Enterorhabdus caecimuris GAM9 from the feces of healthy mice using anaerobic cultivation methods.Animal experiments have shown that GAM9 can reduce the mortality rate and Listeria monocytogenes bacterial load in feces of Lm infected mice,and downregulate the expression level of IL-1β,IL-6,IL-10,TNF α And IFN-γ in the liver and spleen of infected mice.The results indicate that the isolated strain GAM9,as a potential functional probiotic,can treat Listeria monocytogenes infection.关键词
肠道菌群/筛选/单增李斯特菌/治疗Key words
Gut microbiota/Isolation/Listeria monocytogenes/treatment引用本文复制引用
郭亮,鞠龙飞,巩可,余思奇,刘箐..小鼠肠道细菌E.caecimuris GAM9抑制单增李斯特菌感染的作用研究[J].工业微生物,2024,54(6):69-74,6.基金项目
枣庄学院博士科研启动基金项目(1020722). （1020722）
