解放军医学杂志2024，Vol.49Issue(12)：1444-1451,8.DOI:10.11855/j.issn.0577-7402.0046.2024.0807
脑小血管病血管内皮功能障碍及其生物标志物研究进展
Research progress on vascular endothelial dysfunction and its biomarkers in cerebral small vessel disease
摘要
Abstract
Cerebral small vessel disease(CSVD)is a group of local brain tissue lesions caused by abnormal small vessels in the brain due to different etiologies.The pathogenesis of CSVD is not yet fully understood,and its diagnosis currently mainly relies on clinical imaging examinations.Endothelial cells(ECs)in cerebral blood vessels can play an important role in maintaining the structure and function of the blood-brain barrier,regulating cerebral blood flow,and mediating neurovascular coupling.In recent years,studies have shown that ECs dysfunction plays an important triggering and mediating role in the pathological changes of CSVD,and may even be a key initiating link in its pathogenesis.Moreover,biomarkers related to ECs dysfunction are associated with the severity of CSVD.The review summarizes the role of ECs dysfunction in the pathogenesis of CSVD,and the research progress of related biomarkers,aiming to provide references for the diagnosis and treatment of CSVD.关键词
脑小血管病/血脑屏障/白质高信号/内皮细胞功能障碍/生物标志物Key words
cerebral small-vessel disease/blood-brain barrier/white matter hyperintensities/endothelial cell dysfunction/biomarkers分类
医药卫生引用本文复制引用
张肇泽,焦好,陈颖,郭向阳,李正迁..脑小血管病血管内皮功能障碍及其生物标志物研究进展[J].解放军医学杂志,2024,49(12):1444-1451,8.基金项目
This work was supported by the General Project of National Natural Science Foundation of China(81971012),and the Young Academic Backbone Incubation Fund of Peking University Third Hospital(BYSYFY2021029)国家自然科学基金面上项目(81971012) （81971012）
北京大学第三医院青年学术骨干孵育基金(BYSYFY2021029) （BYSYFY2021029）
