教育生物学杂志2024，Vol.12Issue(6)：427-431,436,6.DOI:10.3969/j.issn.2095-4301.2024.06.002
重复经颅磁刺激对孤独症谱系障碍儿童核心症状及脑功能连接的影响
Effects of repetitive transcranial magnetic stimulation on core symptoms and brain functional connectivity in children with autism spectrum disorder
摘要
Abstract
Objective To investigate the effects of repetitive transcranial magnetic stimulation(rTMS)on core symptoms and brain functional connectivity in children with autism spectrum disorder(ASD).Methods Sixty-five ASD children were randomly divided into a control group and an observation group.The control group received conventional rehabilitation treatment,while the observation group underwent conventional rehabilitation combined with rTMS treatment.Before and after treatment,the autism behavior checklist(ABC)and childhood autism rating scale(CARS)were used to evaluate the core symptoms of ASD.Functional near-infrared spectroscopy(fNIRS)technology was used to detect changes in blood oxygen concentration in the prefrontal cortex,and resting-state functional connectivity(RSFC)of the region of interest(ROI)was analyzed.Results After treatment,the ABC and CARS scores of both groups significantly decreased compared to those before treatment(P<0.05),with the observation group showing a more significant decrease(P<0.05).The fNIRS testing revealed that the RSFC within and between the ROI of ASD children in the observation group was higher than that in the control group after treatment.Among them,there were significant differences in the RSFC within the left and right prefrontal cortex,as well as between the left and right prefrontal lobes and between the left temporal lobe and the left anterior and middle frontal lobes(P<0.05).Conclusion rTMS can effectively improve the core symptoms and brain functional connectivity of children with ASD.关键词
孤独症谱系障碍/重复经颅磁刺激/功能性近红外光谱技术/脑功能连接Key words
autism spectrum disorder/repetitive transcranial magnetic stimulation/functional near-infrared spectroscopy/brain functional connectivity引用本文复制引用
王静,刘芸,黄浩宇,吴金庭,张杨萍,王文娟,刘春明..重复经颅磁刺激对孤独症谱系障碍儿童核心症状及脑功能连接的影响[J].教育生物学杂志,2024,12(6):427-431,436,6.基金项目
云南省科技厅科技计划项目(202401AY070001-022) （202401AY070001-022）
云南省徐开寿专家工作站项目(202405AF140103) （202405AF140103）
云南省教育厅科学研究基金(2024J0303) （2024J0303）
昆明市卫生科技人才培养项目医学科技学科后备人才培养计划[2022-SW(后备)005] （后备）
昆明市卫生健康委员会卫生科研课题(2023-16-01-001) （2023-16-01-001）
