临床误诊误治2025，Vol.38Issue(1)：30-34,5.DOI:10.3969/j.issn.1002-3429.2025.01.008
不同类型间质性肺疾病患者临床特征和肿瘤标志物水平及其发生肺癌影响因素
Clinical Features and Levels of Tumor Markers in Patients with Different Types of Interstitial Lung Diseases and Influencing Factors for the Occur-rence of Lung Cancer
摘要
Abstract
Objective To explore the clinical features,tumor marker levels in patients with different types of intersti-tial lung disease(ILD)and influencing factors of the occurrence of lung cancer,so as to improve the early diagnosis rate of patients combined with lung cancer and avoid delayed diagnosis.Methods A total of 335 patients with ILD admitted from January 2020 to December 2022 were selected.According to the high-resolution CT findings and laboratory examination,the patients were divided into idiopathic pulmonary fibrosis(IPF)group(n=106),non-IPF group(n=124),and connective tissue disease-associated ILD(CTD-ILD)group(n=105).General data,incidence of lung cancer,serum tumor markers[carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),neuron-specific enolase(NSE),cytokeratin-19 fragment antigen 21-1(CYFRA21-1),squamous cell carcinoma antigen(SCC),and pro-gastrin-releasing peptide(ProGRP)]were compared among the three groups.Multivariate logistic regression analysis was used to analyze the risk fac-tors affecting the occurrence of lung cancer.Results The levels of CEA,CA125,NSE and CYFRA21-1 in IPF group were higher than those in non-IPF group and CTD-ILD group(P＜0.05),and there were no significant differences in serum SCC and ProGRP in IPF group(P＞0.05).The incidence of lung cancer in IPF group was 55.66%(59/106),which was higher than that in non-IPF group[18.55%(23/124)]and CTD-ILD group[23.81%(25/105)](P＜0.05).The proportion of patients with ILD≥60 years,smoking,coughing sputum and hemoptysis were higher than those without lung cancer(P＜0.05).Age≥60 years,smoking and IPF were the risk factors for lung cancer in patients with ILD(P＜0.05).Conclusion IPF patients had the highest proportion of lung cancer,and serum CEA,CA125,NSE,and CYFRA21-1 levels were higher than those of non-IPF and CTD-ILD patients.Clinical attention should be paid to patients with ILD with risk factors such as age≥60 years,smoking,and IPF,which can effectively improve the early diagnosis rate of complicated lung cancer and avoid delayed diagnosis.关键词
间质性肺疾病/特发性肺纤维化/肺癌/癌胚抗原/糖类抗原125/神经元特异性烯醇化酶/细胞角蛋白-19片段抗原21-1/危险因素Key words
Interstitial lung disease/Idiopathic pulmonary fibrosis/Lung cancer/Carcinoembryonic antigen/Carbo-hydrate antigen 125/Neuron-specific enolase/Cytokeratin-19 fragment antigen 21-1/Risk factor分类
临床医学引用本文复制引用
李修泽,王静,邢颜平,刘晓,刘月..不同类型间质性肺疾病患者临床特征和肿瘤标志物水平及其发生肺癌影响因素[J].临床误诊误治,2025,38(1):30-34,5.基金项目
沧州市重点研发计划自筹项目(222106078) （222106078）
