临床误诊误治2025，Vol.38Issue(1)：35-39,5.DOI:10.3969/j.issn.1002-3429.2025.01.009
紫杉烷类抗肿瘤药物外周神经毒性不良反应的监测与影响因素分析
Monitoring of Peripheral Neurotoxic Adverse Effects of Taxane Antitumor Drugs and Analysis of Influencing Factors
摘要
Abstract
Objective To monitor peripheral neurotoxic adverse effects of Taxane antitumor drugs and to analyze the influencing factors.Methods A total of 180 patients receiving chemotherapy with Taxane antitumor drugs from January 2020 to December 2023 were selected as the research subjects and divided into occurrence group and non-occurrence group accord-ing to presence or absence of peripheral neurotoxic adverse reactions.The clinical data of patients were analyzed,and the oc-currence of peripheral neurotoxic adverse reactions during treatment was observed.The influencing factors of peripheral neuro-toxic adverse reactions in patients treated with Taxane antitumor drugs were analyzed by multivariate logistic regression.Re-sults The incidence of peripheral neurotoxic adverse reactions was 31.11%(56/180)in patients treated with Taxane antitu-mor drugs,mainlyⅠ-Ⅱdegree,accounting for92.86%(52/56).The main clinical manifestations of peripheral neurotoxic adverse reactions were extremity numbness,fatigue and tactile change,which mainly occurred at 12-＜72 h after medication,and the highest incidence was found at 24-＜48 h after medication.Older age,combined diabetes mellitus,higher clinical stage,higher cumulative dose of chemotherapy drugs,and more severe liver function injury were the risk factors for peripheral neurotoxic adverse reactions in patients treated with Taxane antitumor drugs(P＜0.01).Conclusion The incidence of pe-ripheral neurotoxic adverse reactions of Taxane antitumor drugs was relatively high,mainly mild reactions.Older age,diabetes mellitus,higher clinical stage,higher cumulative dose of chemotherapy drugs and more severe liver function injury are high risk factors,which should be paid clinical attention and preventive measures should be formulated.关键词
紫杉烷类/抗肿瘤药物/外周神经毒性/不良反应/年龄/糖尿病/临床分期/危险因素Key words
Taxanes/Antitumor drugs/Peripheral neurotoxicity/Adverse reactions/Age/Diabetes mellitus/Clini-cal stage/Risk factors分类
医药卫生引用本文复制引用
聂朋浩,程庆荣..紫杉烷类抗肿瘤药物外周神经毒性不良反应的监测与影响因素分析[J].临床误诊误治,2025,38(1):35-39,5.基金项目
安徽省医学会课题项目(KY2021009) （KY2021009）
