临床误诊误治2025，Vol.38Issue(1)：40-44,5.DOI:10.3969/j.issn.1002-3429.2025.01.010
基于术前钼靶影像及病理特征分析乳腺癌保乳术病理切缘阳性相关因素
Analysis of Related Factors of Pathologically Positive Margin after Breast-conserving Surgery for Breast Cancer Based on Preoperative Mammogra-phy and Pathological Features
摘要
Abstract
Objective To analyze the factors related to pathologically positive resection margin after breast-conserving surgery(BCS)for breast cancer based on preoperative mammography and pathological features.Methods A total of 202 pa-tients undergoing BCS from January 2019 to December 2022 were selected and divided into positive resection margin group(n=65)and negative resection margin group(n=137)according to pathological conditions.The general data,pathological features and preoperative molybdenum imaging characteristics of the two groups were compared,and the risk factors of patho-logically positive margin after BCS for breast cancer were analyzed by multivariate logistic regression analysis.Results There were significant differences between the two groups with respect to the presence of ductal carcinoma in situ,histological stage,expression of human epidermal growth factor receptor-2(HER-2)and size of the mass(P＜0.05).Multivariate logistic re-gression analysis showed that ductal carcinoma in situ,high histological stage,positive HER-2 expression and large mass were independent risk factors for pathologically positive margin after BCS for breast cancer(P＜0.05).Conclusion Ductal carci-noma in situ,high histological stage,positive HER-2 expression and large mass are the risk factors for pathologically positive margin after BCS for breast cancer.For patients with risk factors of positive resection margin,the scope of resection of tumor and surrounding tissue could be evaluated by preoperative puncture pathology and molybdenum target imaging,which could en-sure the safe boundary of resection margin without increasing the width of resection margin,maintain a good breast appear-ance,improve the postoperative quality of life of patients,ensure the resection effect of BCS for breast cancer,and reduce the rate of secondary surgery.关键词
乳腺癌/保乳术/切缘阳性/钼靶影像/病理特征/危险因素/导管原位癌/人表皮生长因子受体-2Key words
Breast cancer/Breast-conserving surgery/Positive resection margin/Molybdenum target image/Patho-logical features/Risk factor/Ductal carcinoma in situ/Human epidermal growth factor receptor-2分类
医药卫生引用本文复制引用
刘美妍,王慧哲,徐静,王炳东,于玺,赵凯华..基于术前钼靶影像及病理特征分析乳腺癌保乳术病理切缘阳性相关因素[J].临床误诊误治,2025,38(1):40-44,5.基金项目
吴阶平医学基金会临床科研专项(320.6750.2023-18-108) （320.6750.2023-18-108）
