颈动脉超声参数及检验指标与视网膜静脉阻塞的相关分析OACSTPCD
Correlation analysis of carotid ultrasound parameters and examination indexes with retinal vein occlusion
目的 分析颈动脉超声参数及外周血检验指标与视网膜静脉阻塞(RVO)的相关性,探究RVO发病的危险因素、发病机制及生物学预测指标.方法 回顾性临床研究.选取2021年12月至2023年11月于安徽理工大学第一附属医院确诊为RVO住院患者54例作为研究组,均单眼发病,其中视网膜中央静脉阻塞(CRVO)32例,分支静脉阻塞(BRVO)22例,另选取同期眼科非RVO患者54例为对照组,两组均进行颈动脉超声检查和外周血检验,比较两组不同参数的差异情况.结果(1)RVO组颈动脉参数收缩期峰值流速(PSV)、舒张期末期流速(EDV)低于对照组(P<0.05);血流阻力指数(RI)、颈动脉内中膜厚度(IMT)高于对照组(P<0.05).(2)RVO组检验指标中性粒细胞绝对值(N)、血小板和淋巴细胞比值(PLR)、中性粒细胞和淋巴细胞比值(NLR)大于对照组(P<0.05),而淋巴细胞绝对值(L)小于对照组(P<0.05);RVO组PLT大于对照组(P>0.05),两组差异无统计学意义.(3)多因素Logistic回归结果:NLR、PLR的升高以及L降低是RVO发病的独立危险因素.(4)受试者工作曲线(ROC)分析:L预测RVO的曲线下面积(AUC)为0.888(P<0.05),NLR计数预测RVO的AUC为0.891(P<0.05),PLR计数预测RVO的AUC为0.873(P<0.05).结论 颈动脉超声参数及外周血检验指标与RVO关系密切,能够评估RVO患病的风险,为早期预防和治疗提供一定的参考依据.
Objective To analyze the correlation between carotid ultrasound parameters and retinal vein occlu-sion(RVO),and to explore the risk factors,pathogenesis and biological prediction of RVO.Methods Retrospective clinical study.A total of 54 inpatients diagnosed with retinal vein obstruction in the First Affiliated Hospital of Anhui Uni-versity of Science and Technology from December 2021 to November 2023 were selected as the study group,all of whom developed monocular disease,including 32 cases of central retinal vein obstruction and 22 cases of branch vein obstruc-tion,and 54 cases of non-retinal vein occlusion in the same period were selected as the control group.Carotid ultrasound and peripheral blood test were performed in both groups to compare the difference of different parameters between the two groups.Results(1)Carotid artery parameters PSV and EDV in RVO group were lower than those in control group(P<0.05);RI and IMT were higher than those in control group(P<0.05).(2)the indexes of N,PLR and NLR in RVO group were higher than those in control group(P<0.05),while L was lower than that in control group(P<0.05);PLT in RVO group was higher than that in control group(P>0.05),and there was no significant difference between the two groups.(3)Multivariate Logistic regression results:the increase of NLR and PLR and the decrease of L were independent risk factors for RVO.(4)ROC curve analysis:the AUC of L predicted RVO was 0.888(P<0.05),the AUC of NLR count predicted RVO was 0.891(P<0.05),and the AUC of PLR count predicted RVO was 0.873(P<0.05).Conclusions Carotid ar-tery ultrasound parameters and test indicators are closely related to retinal vein occlusion,which can evaluate the risk of RVO and provide a certain reference basis for early prevention and treatment.
尹玉良;方严;臧铭瑄;杨燕;邱翠
232007 淮南,安徽理工大学第一附属医院(淮南市第一人民医院)232007 淮南,安徽理工大学第一附属医院(淮南市第一人民医院)232007 淮南,安徽理工大学第一附属医院(淮南市第一人民医院)232007 淮南,安徽理工大学第一附属医院(淮南市第一人民医院)232007 淮南,安徽理工大学第一附属医院(淮南市第一人民医院)
视网膜静脉阻塞颈动脉超声预测相关性
Retinal vein occlusionCarotid ultrasoundPredictionRelevance
《临床眼科杂志》 2024 (6)
491-494,4
淮南市指导性科技计划项目(2023203)安徽省卫生健康科研项目(AHWJ2023A30019)
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