临床眼科杂志2024，Vol.32Issue(6)：495-499,5.DOI:10.3969/j.issn.1006-8422.2024.06.004
视网膜静脉阻塞继发黄斑水肿抗炎和抗VEGF治疗后SD-OCT生物标志物的观察
Observation of SD-OCT biomarkers after anti-inflammatory and anti-VEGF treatment for macular edema secondary to retinal vein occlusion
摘要
Abstract
Objective To evaluate the changes in visual function and spectral domain optical coherence tomogra-phy(SD-OCT)biomarkers in patients with retinal vein obstruction secondary macular edema(RVO-ME)after anti-inflammatory and anti-vascular endothelial growth factor(VEGF)treatment,and to provide evidence for clinical selection of appropriate treatment.Methods For prospective study,106 patients(106 eyes)diagnosed with RVO-ME in the Affili-ated Hospital of Heze Medical College from June 2019 to November 2021 were randomly divided into two groups:A and B.Group A was given intravitreal injection of Ranibizumab,group B was given intravitreal injection of dexamethasone.Bio-markers of best corrected visual acuity(BCVA)and SD-OCT and adverse reactions were recorded at baseline and 12mo af-ter the first treatment,and changes in BCVA and SD-OCT and incidence of adverse reactions were compared between the two groups before and after treatment.Results BCVA and SD-OCT biomarkers were significantly improved in both groups after treatment(P<0.01).Serous retinal detachment(SRD)degradation in group B was significantly better than that in group A at 12mo,and the number of hyperreflective retinal foci(HRFs)in group B was significantly less than that in group A after the treatment.Compared with the two groups,there was no statistical significance in the changes of external retinal membrane(ELM),ellipsoid zone(EZ)and thedisorganization of retinal innerlayers(DRIL)(P>0.05).There was no significant difference in the incidence of subconjunctival hemorrhage and lens opacity between the two groups after treatment,but 10 patients in group B showed increased intraocular pressure(IOP),which was significantly higher than that in group A.Conclusions Both anti-inflammatory and anti-VEGF treatment were effective for RVO-ME,BCVA and SD-OCT biomarkers were improved,anti-inflammatory treatment was superior to anti-VEGF treatment in improving SRD,and there was no difference between anti-inflammatory and anti-VEGF treatment in the number of HRFs.关键词
黄斑水肿/频域相干光层析成像术/生物标志物/抗炎/抗血管内皮生长因子治疗Key words
Macular edema/Spectral domain optical coherence tomography/Biomarkers/Anti-inflammatory therapy/Anti-vascular endothelial growth factor therapy引用本文复制引用
毕双双,戴馨,崔京卫,平继花,辛贺贺..视网膜静脉阻塞继发黄斑水肿抗炎和抗VEGF治疗后SD-OCT生物标志物的观察[J].临床眼科杂志,2024,32(6):495-499,5.基金项目
2021年山东省医药卫生科技发展计划项目(202107021084) （202107021084）
