临床眼科杂志2024，Vol.32Issue(6)：526-530,5.DOI:10.3969/j.issn.1006-8422.2024.06.010
圆锥角膜和顿挫期圆锥角膜的生物力学分析对比及鉴别诊断
Comparison and differential diagnosis of biomechanical analysis between keratoconus and form fruste kera-toconus
摘要
Abstract
Objective To analyze and compare the biomechanical parameters of keratoconus,form fruste kerato-conus,and normal cornea,explore the application value of corneal visualization scheimpflug technology(Corvis ST)in the early diagnosis of keratoconus and clinical keratoconus.Methods A retrospective study.37 cases(37 eyes)of diag-nosed unilateral keratoconus patients were included.The other eye had a form fruste keratoconus;99 patients(99 eyes)with refractive errors.Perform corneal biomechanical examination on three groups of patients using Corvis ST.SPSS 22.0 statistical software will be used to analyze the data,and normal selection analysis of variance or Kruskal Wallis H-test will be used based on whether the patient data meets the criteria.Perform receiver operating characteristic(ROC)analysis on biomechanical parameters,with positive results for parameters with an area under the ROC curve(AUC)greater than 0.7,and record in the table.Results All biomechanical parameters included in the study showed statistical differencesbe-tween the keratoconus group and the normal cornea group(P<0.05).The number of differences in biomechanical param-eters of keratoconus VS form fruste keratoconus and form fruste keratoconus VS normal cornea group decreased.The biome-chanical parameter corvis biomechanical index(CBI)has the highest diagnostic efficiency for keratoconus,with a relative AUC value of 0.992 for normal corneas and 0.938 for form fruste corneas.Compared to normal corneas,DA Ratio Max(1 mm)has a higher diagnostic efficiency for form fruste keratoconus,with an AUC value of 0.797.Conclusions There are biomechanical differences in keratoconus,form fruste keratoconus,and normal cornea.CBI has the highest diagnostic effi-ciency for keratoconus,and biomechanical parameters such as DA Ratio Max(1 mm)have a high diagnostic efficiency for form fruste keratoconus.关键词
顿挫期圆锥角膜/圆锥角膜/生物力学/可视化角膜生物力学分析仪Key words
Form fruste Keratoconus/Keratoconus/Biomechanical/Corvis ST引用本文复制引用
武志清,魏升升,张耀花,李勇,苏希蕊,杨丹,薛亚林,高金荣,李晶..圆锥角膜和顿挫期圆锥角膜的生物力学分析对比及鉴别诊断[J].临床眼科杂志,2024,32(6):526-530,5.基金项目
西安市科技计划项目(22YXYJ0054) （22YXYJ0054）
陕西省科技计划项目(S2024-YF-YBSF-0599,2024SF-YBXM-331) （S2024-YF-YBSF-0599,2024SF-YBXM-331）
