临床眼科杂志2024，Vol.32Issue(6)：568-575,8.DOI:10.3969/j.issn.1006-8422.2024.06.022
激光光凝术在糖尿病性黄斑水肿中的应用进展
Laser photocoagulation in the treatment of diabetic macular edema:a review
摘要
Abstract
Diabetic macular edema(DME)is one of the primary causes of central visual impairment in diabetic patients.Before the advent of anti-vascular endothelial growth factor(anti-VEGF)therapies,laser photocoagulation was the primary intervention for DME.The clinical application of conventional laser photocoagulation in DME has been rel-egated from its erstwhile status as a first-line treatment option due to its potential damage to retinal structures.In recent years,however,with the modifications in laser parameters and operational modalities,novel laser technologies,such as subthreshold micropulse laser photocoagulation and selective retinal therapy,have emerged as promising treatment alterna-tives for DME.The modified lasers selectively target retinal pigment epithelium and cause minimal damage to the neuroepi-thelial tissue,enabling a high safety profile.As an adjunctive therapy to intravitreal anti-VEGF injections,micropulse la-ser therapy offers a dual benefit by maintaining treatment efficacy while reducing the frequency of injections,thereby alle-viating the treatment burden on patients.Moreover,for individuals exhibiting suboptimal responses to anti-VEGF therapy,micropulse laser treatment has demonstrated potential advantages.This article aims to provide a comprehensive overview of the application and recent advancements of macular laser therapy in the management of DME.关键词
糖尿病性黄斑水肿/激光光凝术/值下微脉冲激光/选择性视网膜疗法/视网膜色素上皮Key words
Diabetic macular edema/Laser photocoagulation/Subthreshold micropulse laser/Selective retinal therapy/Retinal pigment epithelium引用本文复制引用
谢碧瑶,黄梓敬..激光光凝术在糖尿病性黄斑水肿中的应用进展[J].临床眼科杂志,2024,32(6):568-575,8.基金项目
国家自然科学基金(82101112) （82101112）
汕头市医疗卫生科技计划项目[汕府科[2022)169号-101] （）
