临床与实验病理学杂志2024，Vol.40Issue(12)：1305-1311,7.DOI:10.13315/j.cnki.cjcep.2024.12.012
原发性肝脏黏液表皮样癌4例临床病理分析并文献复习
Primary hepatic mucoepidermoid carcinoma:clinicopathologic analysis of 4 cases and literature review
摘要
Abstract
Purpose To investigate the clinicopathological features of primary mucoepidermoid carcinoma of the liver(PMCL).Methods The history,clinical data,pathological diagnosis,differential diagnosis,treatment and prognosis of 4 patients with PMCL were retrospectively analyzed.Results All four tumors were located in the left half of the liver and were sol-itary.Microscopic examination showed that tumor cells were composed of three types of cells:epidermal like cells,interme-diate cells,and mucinous cells,with varying proportions.Im-munophenotype:tumor cells showed diffuse strong positivity for CA199 and CK19,while mucous cells showed focal positivity for CEA.CK7 mainly expressed in epidermal like cells and mucous cells,while CK5/6,p40,and p63 expressed in epidermal like cells and intermediate cells.Special staining with AB,PAS,and mucin carmine confirmed the presence of mucous cells,Ki67 proliferation index ranged from 30％to 40％.FISH testing:no MAML2 gene breakage or rearrangement was detected in 4 cases of PMCL,and MAML2 gene amplification occurred in 1 case of tumor.Conclusion The incidence of PMCL is low and present with non-specific clinical manifestations,which often leads to misdiagnosis.The diagnosis should be differentiated from bile duct adenocarcinoma and adenosquamous carcinoma.Moreover,there is currently no established standard treatment for PMCL and has a poor prognosis.关键词
肝肿瘤/黏液表皮样癌/临床病理特征/分子病理学Key words
liver tumor/mucoepidermoid carcinoma/clinico-pathologic features/molecular pathology分类
医药卫生引用本文复制引用
顾倩,王小明,卢林明,黄曦,李佳嘉,汪向明,郭娜娜..原发性肝脏黏液表皮样癌4例临床病理分析并文献复习[J].临床与实验病理学杂志,2024,40(12):1305-1311,7.基金项目
安徽省临床医学研究转化专项项目(202204295107020059) （202204295107020059）
