岭南现代临床外科2024，Vol.24Issue(6)：347-353,7.DOI:10.3969/j.issn.1009-976X.2024.06.002
基于竞争风险模型探索术前间接胆红素/总胆红素比值在胃癌中的预后价值
Preoperative indirect bilirubin to total bilirubin ratio:a novel rognostic factor for gastric cancer based on competing risk model
摘要
Abstract
Background Besides its adverse effect,bilirubin,especially indirect bilirubin,also serves as a potent antioxidant and could influence the formation and development of carcinoma.The correlation between bilirubin with clinical outcome has been widely validated in several malignancies,nevertheless,whether bilirubin is capable of being a prognosis indicator in gastric cancer remains disputable.Methods We retrospectively reviewed 1245 gastric cancer(GC)patients who received radical or palliative gastrec-tomy at Sun Yat-Sen University Cancer Center and Shenshan Medical Center,Sun Yat-Sen Memorial Hospital from 2008 to 2023.Fine and Gray competing risk model was conducted to evaluate prognostic significance of clinicopathological factors and bilirubin.Results We derived a novel index,Indirect Bilirubin to Total Bilirubin Ratio(ITR)and explored its role in predicting prognosis of GC patients with curative/palliative surgery by utilizing competing risk regression model.At first time,we found patients with ITR>0.69 had relatively better prognosis(HR,0.72;95%CI,0.61-0.84;P<0.001).Conclusion Our study indicated that preoperative ITR could act as an independent prognostic factor in GC.关键词
胆红素/胃癌/预后/竞争风险模型Key words
bilirubin/gastric cancer/prognosis/competing risk model分类
医药卫生引用本文复制引用
马明哲,袁庶强,闵筱辉..基于竞争风险模型探索术前间接胆红素/总胆红素比值在胃癌中的预后价值[J].岭南现代临床外科,2024,24(6):347-353,7.基金项目
广东省自然科学基金(2016A030313316) （2016A030313316）
