岭南现代临床外科2024，Vol.24Issue(6)：360-365,6.DOI:10.3969/j.issn.1009-976X.2024.06.004
吲哚菁绿荧光示踪法、亚甲蓝示踪法及二者联合应用在乳腺癌前哨淋巴结活检术中的临床应用价值
Clinical application value of indocyanine green fluorescence tracing,methylene blue tracing,and their combined use in sentinel lymph node biopsy for breast cancer
摘要
Abstract
Objective We aimed to assess the efficacy,safety,and practicality of indocyanine green(ICG),methylene blue(MB),and their combination in sentinel lymph node biopsy(SLNB).Methods From August 2021 to August 2022,a total of 180 early-stage female breast cancer patients were enrolled and randomly assigned to three groups:the indocyanine green(ICG group,60 cases),the methylene blue(methylene blue group,60 cases),and the combination of indocyanine green and methylene blue(combination group,60 cases)for sentinel lymph node biopsy.The primary endpoint of the study was the success rate of sentinel lymph node biopsy among the three groups.Results In the ICG group,senti-nel lymph node biopsy was successful in 58 cases(success rate of 96.67%,95%CI:88.47-99.59);in the methylene blue group,biopsy was successful in 56 cases(success rate of 93.33%,95%CI:83.80-98.15);and in the combination group,biopsy was successful in all 60 cases(success rate of 100%,95%CI:94.04-100.00).This study demonstrates that the success rates of sentinel lymph node biopsy are high in all groups-ICG,methylene blue,and combination-and there is no significant difference in success rates among the groups(P=0.168).Conclusion The detection rate of sentinel lymph nodes(SLNs)achieved with ICG fluorescence tracing is comparable to that attained with methylene blue trac-ing.However,the dual-tracing technique that integrates ICG with methylene blue demonstrates an even higher detection rate.Consequently,both single ICG fluorescence tracing and the combined approach of ICG and methylene blue dual-tracing are viable options for sentinel lymph node biopsy(SLNB)in patients diagnosed with early-stage breast cancer.关键词
吲哚菁绿/亚甲蓝/前哨淋巴结/乳腺癌Key words
indocyanine green/methylene blue/sentinel lymph node/breast cancer分类
医药卫生引用本文复制引用
方勤,陈淑如,彭鸿彬,黄宇康..吲哚菁绿荧光示踪法、亚甲蓝示踪法及二者联合应用在乳腺癌前哨淋巴结活检术中的临床应用价值[J].岭南现代临床外科,2024,24(6):360-365,6.基金项目
吴阶平医学基金会临床科研专项资助基金(320.6750.2021-10-65). （320.6750.2021-10-65）
